In-silico discovery of novel estrogen receptor-α inhibitors as potential therapeutics for tamoxifen resistant breast cancer

被引:0
|
作者
Singh, Kriti [1 ]
Munuganti, Ravi S. N. [1 ]
Butler, Miriam [1 ]
Cherkasov, Artem [1 ]
Rennie, Paul S. [1 ]
机构
[1] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V5Z 1M9, Canada
关键词
D O I
10.1158/1538-7445.SABCS14-PD6-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PD6-7
引用
收藏
页数:2
相关论文
共 50 条
  • [1] In-silico identification of potential inhibitors targeting the DNA binding domain of estrogen receptor α for the treatment of hormone therapy-resistant breast cancer
    Bouricha, El Mehdi
    Hakmi, Mohammed
    Akachar, Jihane
    Zouaidia, Fouad
    Ibrahimi, Azeddine
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (11): : 5203 - 5210
  • [2] A new class of estrogen receptor-α (ERα) inhibitors to treat tamoxifen-resistant breast cancers
    Singh, Kriti
    Munuganti, Ravi S. N.
    Butler, Miriam
    Leblanc, Eric
    Cherkasov, Artem
    Rennie, Paul S.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 : S19 - S19
  • [3] Drug Screening of Potential Multiple Target Inhibitors for Estrogen Receptor-α-positive Breast Cancer
    Dai, Yun-Hao
    Chen, Guan-Yu
    Tang, Chih-Hsin
    Huang, Wei-Chien
    Yang, Juan-Cheng
    Wu, Yang-Chang
    [J]. IN VIVO, 2021, 35 (02): : 761 - 777
  • [4] OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells
    Bhatt, S.
    Stender, J. D.
    Joshi, S.
    Wu, G.
    Katzenellenbogen, B. S.
    [J]. ONCOGENE, 2016, 35 (44) : 5722 - 5734
  • [5] OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells
    S Bhatt
    J D Stender
    S Joshi
    G Wu
    B S Katzenellenbogen
    [J]. Oncogene, 2016, 35 : 5722 - 5734
  • [6] Estrogen Receptor-α Phosphorylation at Serine-118 and Tamoxifen Response in Breast Cancer
    Kok, Marleen
    Holm-Wigerup, Caroline
    Hauptmann, Michael
    Michalides, Rob
    Stal, Olle
    Linn, Sabine
    Landberg, Goran
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (24) : 1725 - 1729
  • [7] Identification of Halogen-Based Derivatives as Potent Inhibitors of Estrogen Receptor Alpha of Breast Cancer: An In-Silico Investigation
    Saba, Afsheen
    Muhammad, Shabbir
    Khera, Rasheed Ahmad
    Alhujaily, Muhanad
    Iqbal, Javed
    Chaudhry, Aijaz Rasool
    Alarfaji, Saleh S.
    Belali, Tareg M.
    [J]. JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY, 2022, 21 (02): : 181 - 205
  • [8] Tamoxifen induced estrogen receptor activity in endocrine resistant breast cancer
    不详
    [J]. EJC SUPPLEMENTS, 2006, 4 (02): : 145 - 146
  • [9] Development of novel breast cancer therapeutics for anti-estrogen resistant breast cancer
    Ma, Yongxian
    Preet, Anju
    Hu, Changyan
    Kumar, Akshay
    Ma, James
    Tomita, York
    Rosen, Eliot M.
    [J]. CANCER RESEARCH, 2013, 73 (08)
  • [10] Immunohistochemical determination of estrogen receptor-α phosphorylation in activation function AF1 in primary and tamoxifen-resistant breast cancer is indicative of a complex role for estrogen receptor-α phosphorylation in breast cancer progression.
    Ali, S.
    Sarwar, N.
    Jiang, J.
    Peston, D.
    Sinnett, H. D.
    Madden, P.
    Shousha, S.
    Lykkesfeldt, A. E.
    Gee, J. M.
    Nicholson, R., I
    Kulinskaya, E.
    Coombes, R. C.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2006, 100 : S36 - S37