Toll-like receptor-dependent lipid body formation in macrophage foam cell formation

被引：27
|
作者：
Nicolaou, Giovanna [1 ]
Erridge, Clett [1 ]
机构：
[1] Univ Leicester, Glenfield Gen Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England
来源：
CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期
关键词：
atherosclerosis; lipid bodies; lipid droplets; macrophage foam cells; Toll-like receptors; CASSETTE TRANSPORTER A1; CHLAMYDIA-PNEUMONIAE; MYCOBACTERIUM-LEPRAE; MURINE MACROPHAGES; PPAR-GAMMA; IN-VIVO; EXPRESSION; ALPHA; AGONISTS; ACCUMULATION;
D O I：
10.1097/MOL.0b013e32833cacd5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TLR stimulation promotes the accumulation of lipid bodies in macrophages and consequently foam cell formation. The pathways responsible for these processes may constitute novel therapeutic targets for atherosclerosis.
引用
收藏
页码：427 / 433
页数：7
相关论文
共 50 条
  • [41] Toll-Like Receptor 5 Modulates Myd88-Dependent Toll-Like Receptor 4 Signaling
    Johnson, C. G.
    Sciurba, J.
    Rice, A.
    Aloor, J.
    Cyphert, J.
    Bulek, K.
    Li, X.
    Fessler, M. B.
    Garantziotis, S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [42] Bordetella evolution:: lipid A and Toll-like receptor 4
    MacArthur, Lain
    Mann, Paul B.
    Harvill, Eric T.
    Preston, Andrew
    JOURNAL OF ENDOTOXIN RESEARCH, 2007, 13 (04): : 243 - 247
  • [43] Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4
    Tamai, R
    Asai, Y
    Hashimoto, M
    Fukase, K
    Kusumoto, S
    Ishida, H
    Kiso, M
    Ogawa, T
    IMMUNOLOGY, 2003, 110 (01) : 66 - 72
  • [44] Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
    Zhu, Jiangao
    Huang, Xiaopei
    Yang, Yiping
    JOURNAL OF VIROLOGY, 2007, 81 (07) : 3170 - 3180
  • [45] Early Bacterial Colonization Induces Toll-Like Receptor-Dependent Transforming Growth Factor β Signaling in the Epithelium
    Beisswenger, Christoph
    Lysenko, Elena S.
    Weiser, Jeffrey N.
    INFECTION AND IMMUNITY, 2009, 77 (05) : 2212 - 2220
  • [46] PHAGOCYTOSIS OF AGGREGATED LIPOPROTEIN BY MACROPHAGES - LOW-DENSITY LIPOPROTEIN RECEPTOR-DEPENDENT FOAM-CELL FORMATION
    SUITS, AG
    CHAIT, A
    AVIRAM, M
    HEINECKE, JW
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2713 - 2717
  • [47] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages
    Miyake, Atsuko
    Murata, Yoji
    Okazawa, Hideki
    Ikeda, Hiroshi
    Niwayama, Yuriko
    Ohnishi, Hiroshi
    Hirata, Yukio
    Matozaki, Takashi
    GENES TO CELLS, 2008, 13 (02) : 209 - 219
  • [48] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
    Kawagoe, Tatsukata
    Sato, Shintaro
    Matsushita, Kazufumi
    Kato, Hiroki
    Matsui, Kosuke
    Kumagai, Yutaro
    Saitoh, Tatsuya
    Kawai, Taro
    Takeuchi, Osamu
    Akira, Shizuo
    NATURE IMMUNOLOGY, 2008, 9 (06) : 684 - 691
  • [49] Toll-like receptor activation in bacterial pneumonia increases lung cancer cell adhesion and metastasis formation
    Gowing, Stephen D.
    Chow, Simon C.
    Cools-Lartigue, Jonathan J.
    Chen, Crystal B.
    Giannias, Betty
    Bourdeau, France
    Rousseau, Simon
    Qureshi, Salman T.
    Ferri, Lorenzo E.
    CANCER RESEARCH, 2014, 74 (19)
  • [50] PLACENTAL GROWTH FACTOR ENHANCES TOLL-LIKE RECEPTOR-DEPENDENT INFLAMMATORY RESPONSES IN HUMAN MONONUCLEAR PHAGOCYTES
    Newell, Laura
    Holtan, Shernan
    Yates, Jane
    Pereira, Leonardo
    Enninga, Elizabeth Ann
    Creedon, Douglas
    Markovic, Svetomir
    Tyner, Jeffrey
    Burd, Irina
    Bagby, Grover
    PLACENTA, 2016, 45 : 88 - 89
12345