Toll-like receptor-dependent lipid body formation in macrophage foam cell formation

被引：27
|
作者：
Nicolaou, Giovanna [1 ]
Erridge, Clett [1 ]
机构：
[1] Univ Leicester, Glenfield Gen Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England
来源：
CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期
关键词：
atherosclerosis; lipid bodies; lipid droplets; macrophage foam cells; Toll-like receptors; CASSETTE TRANSPORTER A1; CHLAMYDIA-PNEUMONIAE; MYCOBACTERIUM-LEPRAE; MURINE MACROPHAGES; PPAR-GAMMA; IN-VIVO; EXPRESSION; ALPHA; AGONISTS; ACCUMULATION;
D O I：
10.1097/MOL.0b013e32833cacd5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TLR stimulation promotes the accumulation of lipid bodies in macrophages and consequently foam cell formation. The pathways responsible for these processes may constitute novel therapeutic targets for atherosclerosis.
引用
收藏
页码：427 / 433
页数：7
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