Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

被引：51
|
作者：
Xu, Fa-Wei [1 ]
Lv, Ying-Li [2 ]
Zhong, Yu-Fan [1 ]
Xue, Ya-Nan [1 ]
Wang, Yong [1 ]
Zhang, Li-Yun [1 ]
Hu, Xian [1 ]
Tan, Wei-Qiang [1 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Plast Surg, Sch Med, 3 East Qingchun Rd, Hangzhou 310016, Peoples R China
[2] Zhejiang Univ, Coll Agr & Biotechnol, Tea Res Inst, Hangzhou 310013, Peoples R China
来源：
MOLECULES | 2021年 / 26卷 / 20期
基金：
中国国家自然科学基金;
关键词：
EGCG; skin wound healing; wound dressing; anti-inflammation; angiogenesis; antifibrosis; EPIGALLOCATECHIN GALLATE; GROWTH-FACTOR; (-)-EPIGALLOCATECHIN GALLATE; THIOREDOXIN REDUCTASE; BACTERIAL THIOREDOXIN; HUMAN KERATINOCYTES; GOLD NANOPARTICLES; KELOID FIBROBLASTS; ASCORBIC-ACID; ANTIBACTERIAL;
D O I：
10.3390/molecules26206123
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.</p>
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页数：16
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