Converting Tumoral PD-L1 into a 4-1BB Agonist for Safer and More Effective Cancer Immunotherapy

被引：4

作者：

Li, Zihai ^{[1
,2
]}

Azar, Joseph H. ^{[1
,2
]}

Rubinstein, Mark P. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Div Med Oncol, Dept Internal Med, Columbus, OH USA

[2] Ohio State Univ, James Comprehens Canc Ctr, Plotonia Inst Immunooncol, 460 W 12th Ave,BRT 510,Biomed Res Tower, Columbus, OH 43210 USA

来源：

CANCER DISCOVERY | 2022年 / 12卷 / 05期

关键词：

D O I：

10.1158/2159-8290.CD-22-0219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dose-limiting toxicities are thought to temper the efficacy of single-agent 4-1BB agonists. To overcome this hurdle, in this issue of Cancer Discovery, Muik and colleagues report preclinical and clinical studies describing a first-in-class bispecific fusion protein targeting 4-1BB and PD-L1.

引用

页码：1184 / 1186

页数：3

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