An efficient FeCl3-catalyzed amidation reaction of secondary benzylic and allylic alcohols with carboxamides or p-toluenesulfonamide

被引：114
|
作者：
Jana, Umasish [1 ]
Maiti, Sukhendu [1 ]
Biswas, Srijit [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 05期
关键词：
ferric chloride; amidation reactions; alcohols; atom-economical; inexpensive;
D O I：
10.1016/j.tetlet.2007.11.176
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, inexpensive, environmentally friendly and high yielding amidation reaction of benzylic and allylic alcohols with primary amides using a catalytic amount of FeCl3 (5 mol %) is described. Direct substitution of various amides such as benzamide, sulfonamide, acetamide and acrylamide is reported, and this method also works on a large scale in high yield. (C) 2007 Elsevier Ltd. All rights reserved.
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页码：858 / 862
页数：5
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