Emetine and the alternative splicing of Bcl-x: Where to next?

被引：0

作者：

Shultz, Jacqueline C. ^{[1
]}

Chalfant, Charles E. ^{[1
,2
,3
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem, Richmond, VA 23298 USA

[2] Hunter Holmes McGuire Vet Adm Med Ctr, Richmond, VA 23249 USA

[3] Massey Canc Ctr, Richmond, VA 23298 USA

来源：

CHEMISTRY & BIOLOGY | 2007年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.chembiol.2007.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interference with the alternative splicing of apoptotic factors offers an innovative and specific mechanism to target malignant cells. In this issue of Chemistry & Biology, Zhou et al. [1] report on the regulation of the alternative splicing of Bcl-x pre-mRNA in response to emetine, a potent protein synthesis inhibitor, as well as define a major player in the signaling mechanism.

引用

页码：1313 / 1314

页数：2

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