Emetine and the alternative splicing of Bcl-x: Where to next?

被引：0
|
作者：
Shultz, Jacqueline C. [1 ]
Chalfant, Charles E. [1 ,2 ,3 ]
机构：
[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem, Richmond, VA 23298 USA
[2] Hunter Holmes McGuire Vet Adm Med Ctr, Richmond, VA 23249 USA
[3] Massey Canc Ctr, Richmond, VA 23298 USA
来源：
CHEMISTRY & BIOLOGY | 2007年 / 14卷 / 12期
关键词：
D O I：
10.1016/j.chembiol.2007.12.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interference with the alternative splicing of apoptotic factors offers an innovative and specific mechanism to target malignant cells. In this issue of Chemistry & Biology, Zhou et al. [1] report on the regulation of the alternative splicing of Bcl-x pre-mRNA in response to emetine, a potent protein synthesis inhibitor, as well as define a major player in the signaling mechanism.
引用
收藏
页码：1313 / 1314
页数：2
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