Two cancer stem cell-targeted therapies in clinical trials as viewed from the standpoint of the cancer stem cell model

被引：8
|
作者：
Caras, Ingrid W. [1 ]
机构：
[1] Calif Inst Regenerat Med, 1999 Harrison St, Oakland, CA 94612 USA
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2020年 / 9卷 / 08期
关键词：
ACUTE MYELOID-LEUKEMIA; ROR1; CD47; RITUXIMAB; PHAGOCYTOSIS; MACROPHAGES; SIGNATURE;
D O I：
10.1002/sctm.19-0424
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
A key implication of the cancer stem cell model is that for a cancer therapy to be curative, it is imperative to eliminate the cancer stem cells (CSCs) that drive tumor progression. The California Institute for Regenerative Medicine is supporting two novel approaches that target CSCs, one an antibody-mediated immunotherapy targeting CD47 and the other an antibody targeting ROR1. This article summarizes the evidence that CSCs are targeted and discusses the results of early clinical trials within the context of the CSC model.
引用
收藏
页码：821 / 826
页数：6
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