Ceramide kinase and ceramide-1-phosphate

被引：25
|
作者：
Wijesinghe, Dayanjan S. [1 ]
Lamour, Nadia F.
Gomez-Munoz, Antonio
Chalfant, Charles E.
机构：
[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA
[2] Univ Basque Country, Fac Sci & Technol, Dept Biochem & Mol Biol, Bilbao, Spain
[3] Hunter Holmes McGuire Vet Adm Med Ctr, Res & Dev, Richmond, VA USA
来源：
LIPIDOMICS AND BIOACTIVE LIPIDS: LIPIDS AND CELL SIGNALING | 2007年 / 434卷
关键词：
D O I：
10.1016/S0076-6879(07)34015-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
it has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK). In the following methods chapter, the methodologies for examining CERK function in vitro and in cells are outlined in detail. The methodologies for examining C1P levels and the use of exogenous C1P on cells to observe lipid specific effects on a particular biology are also detailed.
引用
收藏
页码：265 / +
页数：29
相关论文
共 50 条
  • [21] Role of cytosolic phospholipase A2α in cell rounding and cytotoxicity induced by ceramide-1-phosphate via ceramide kinase
    Nakamura, Hiroyuki
    Tada, Eiko
    Makiyama, Tomohiko
    Yasufuku, Kana
    Murayama, Toshihiko
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 512 (01) : 45 - 51
  • [22] Ceramide-1-Phosphate, in Contrast to Ceramide, Is Not Segregated into Lateral Lipid Domains in Phosphatidylcholine Bilayers
    Morrow, Michael R.
    Helle, Anne
    Perry, Joshua
    Vattulainen, Ilpo
    Wiedmer, Susanne K.
    Holopainen, Juha M.
    [J]. BIOPHYSICAL JOURNAL, 2009, 96 (06) : 2216 - 2226
  • [23] Ceramide-1-Phosphate in Cell Survival and Inflammatory Signaling
    Gomez-Munoz, Antonio
    Gangoiti, Patricia
    Granado, Maria H.
    Arana, Lide
    Ouro, Alberto
    [J]. SPHINGOLIPIDS AS SIGNALING AND REGULATORY MOLECULES, 2010, 688 : 118 - 130
  • [24] Ceramide-1-phosphate stimulates glucose uptake in macrophages
    Ouro, A.
    Arana, L.
    Gangoiti, P.
    Gomez-Munoz, A.
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2010, 163 : S37 - S37
  • [25] Ceramide-1-phosphate sugars: New types of glycophospholipids
    Martin, TJ
    Dufner, G
    Kratzer, B
    Schmidt, RR
    [J]. GLYCOCONJUGATE JOURNAL, 1996, 13 (04) : 547 - 553
  • [26] The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis
    Hinkovska-Galcheva, Vania
    VanWay, Susan M.
    Shanley, Thomas P.
    Kunkel, Robin G.
    [J]. CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2008, 9 (11) : 1192 - 1205
  • [27] The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
    Hait, Nitai C.
    Maiti, Aparna
    [J]. MEDIATORS OF INFLAMMATION, 2017, 2017
  • [28] An expedient synthesis of fluorescent labeled ceramide-1-phosphate analogues
    Boldyrev, I. A.
    Brown, R. E.
    Molotkovsky, J. G.
    [J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2013, 39 (05) : 539 - 542
  • [29] Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence
    Millner, Alec
    Running, Logan
    Colon-Rosa, Nicole
    Aga, Diana S.
    Frasor, Jonna
    Atilla-Gokcumen, G. Ekin
    [J]. ACS CHEMICAL BIOLOGY, 2022, 17 (04) : 822 - 828
  • [30] Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate
    Shirey, Carolyn M.
    Ward, Katherine E.
    Stahelin, Robert V.
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2016, 200 : 32 - 41
12345