Ceramide kinase and ceramide-1-phosphate

被引：25
|
作者：
Wijesinghe, Dayanjan S. [1 ]
Lamour, Nadia F.
Gomez-Munoz, Antonio
Chalfant, Charles E.
机构：
[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA
[2] Univ Basque Country, Fac Sci & Technol, Dept Biochem & Mol Biol, Bilbao, Spain
[3] Hunter Holmes McGuire Vet Adm Med Ctr, Res & Dev, Richmond, VA USA
来源：
LIPIDOMICS AND BIOACTIVE LIPIDS: LIPIDS AND CELL SIGNALING | 2007年 / 434卷
关键词：
D O I：
10.1016/S0076-6879(07)34015-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
it has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK). In the following methods chapter, the methodologies for examining CERK function in vitro and in cells are outlined in detail. The methodologies for examining C1P levels and the use of exogenous C1P on cells to observe lipid specific effects on a particular biology are also detailed.
引用
收藏
页码：265 / +
页数：29
相关论文
共 50 条
  • [1] CERAMIDE KINASE, CERAMIDE-1-PHOSPHATE: ROLES AND REGULATION
    Bornancin, Frederic
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2010, 382 : 9 - 9
  • [2] Ceramide kinase, ceramide-1-phosphate: Roles and implication in phagocytosis and phagolysosomal fusion
    Hinkovska-Galcheva, VT
    Kindzelski, AL
    Huang, JB
    Clark, A
    Shanley, T
    Shayman, J
    Petty, H
    Boxer, L
    [J]. FASEB JOURNAL, 2006, 20 (04): : A484 - A484
  • [3] SYNTHESIS OF CERAMIDE-1-PHOSPHATE
    BUSHNEV, AS
    KARPYSHEV, NN
    ZVONKOVA, EN
    EVSTIGNEEVA, RP
    [J]. BIOORGANICHESKAYA KHIMIYA, 1979, 5 (09): : 1381 - 1384
  • [4] Translocation and activation of sphingosine kinase 1 by ceramide-1-phosphate
    Nishino, Shohei
    Yamashita, Hisahiro
    Tamori, Mizuki
    Mashimo, Masato
    Yamagata, Kazuyuki
    Nakamura, Hiroyuki
    Murayama, Toshihiko
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (04) : 5396 - 5408
  • [5] Ceramide kinase and the ceramide-1-phosphate/cPLA2 interaction as a therapeutic target
    Lamour, Nadia F.
    Chalfant, Charles E.
    [J]. CURRENT DRUG TARGETS, 2008, 9 (08) : 674 - 682
  • [6] A Comparison Of Ceramide And Ceramide-1-phosphate Miscibility In Phosphatidylcholine Bilayers
    Morrow, Michael R.
    Helle, Anne
    Perry, Joshua
    Vattulainen, Ilpo
    Wiedmer, Susanne K.
    Holopainen, Juha M.
    [J]. BIOPHYSICAL JOURNAL, 2009, 96 (03) : 162A - 163A
  • [7] Ceramide-1-phosphate directly regulates sphingosine kinase 1 activity
    Nishino, Shohei
    Yamashita, Hisahiro
    Nakamura, Hiroyuki
    Murayama, Toshihiko
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017, 133 (03) : S141 - S141
  • [8] Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice
    Graf, Christine
    Niwa, Satoru
    Mueller, Matthias
    Kinzel, Bernd
    Bornancin, Frederic
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 373 (01) : 159 - 163
  • [9] Effects of Glycerophospholipids on Ceramide Kinase Activity: Cardiolipin-Affected Cellular Formation of Ceramide-1-phosphate
    Matsuzaki, Wataru
    Takahashi, Hiromasa
    Nakamura, Hiroyuki
    Murayama, Toshihiko
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2016, 39 (10) : 1708 - 1717
  • [10] Ceramide-1-phosphate stimulates carbohydrate metabolism
    Ordonez, M.
    Ouro, A.
    Arana, L.
    Rivera, I. G.
    Gangoiti, P.
    Trueba, M.
    Gomez-Munoz, A.
    [J]. FEBS JOURNAL, 2012, 279 : 152 - 152
12345