Pharmacologic Management of Chronic Constipation

被引：26

作者：

Singh, Siddharth ^{[1
]}

Rao, Satish S. C. ^{[1
]}

机构：

[1] Univ Iowa, Univ Iowa Hosp & Clin, Carver Coll Med, Dept Internal Med,Div Gastroenterol Hepatol, Iowa City, IA 52242 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2010年 / 39卷 / 03期

关键词：

Chronic constipation; Medical management; Laxatives; Lubiprostone; Linaclotide; Methylnaltrexone; Alvimopan; Prucalopride; PLACEBO-CONTROLLED TRIAL; OPIOID-INDUCED CONSTIPATION; DOUBLE-BLIND; COST-EFFECTIVENESS; LUBIPROSTONE; EFFICACY; MULTICENTER; METHYLNALTREXONE; ALVIMOPAN; TRANSIT;

D O I：

10.1016/j.gtc.2010.08.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic constipation is a common digestive problem in North America with significant psychosocioeconomic implications Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients Several newer agents that act by increasing colonic peristalsis, altering colonic secretion and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation

引用

页码：509 / +

页数：21

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