Kruppel-like transcription factors: A functional family

被引：318
|
作者：
Pearson, Richard [1 ]
Fleetwood, Jacqueline [2 ]
Eaton, Sally [1 ]
Crossley, Merlin [1 ]
Bao, Shisan [2 ]
机构：
[1] Univ Sydney, Sch Mol & Microbial Biosci, Sydney, NSW 2006, Australia
[2] Univ Sydney, Discipline Pathol, Bosch Inst, Sydney, NSW 2006, Australia
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 10期
关键词：
Klf; transcription factor; gene regulation;
D O I：
10.1016/j.biocel.2007.07.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Kruppel-like factor (Klfs) family of gene regulatory proteins are transcription factors implicated in many biological processes, including proliferation, apoptosis, differentiation and development. The characteristic feature of this family is the presence of three Kruppel-like zinc fingers, which bind to CACCC elements and GC-rich regions of DNA, to mediate activation and/or repression of transcription. In recent years several Klf knockout mice have been generated. The aim of this review is to outline the biological roles of those Klfs as deduced from the gene ablation studies. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1996 / 2001
页数：6
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