Synthesis of pyrazolo[1,5-a] quinoxalin-4(5H)-ones via one-pot amidation/N-arylation reactions under transition metal-free conditions

被引：12

作者：

Wiethan, Carson ^{[1
]}

Franceschini, Steffany Z. ^{[1
]}

Bonacorso, Helio G. ^{[1
]}

Stradiotto, Mark ^{[2
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Dalhousie Univ, Dept Chem, Halifax, NS B3H 4R2, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 37期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CATALYST;

D O I：

10.1039/c6ob01407k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot transition metal-free procedure for the synthesis of new pyrazolo[1,5-a] quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate) pyrazoles and various primary alkylamines is described. The key steps involved in the synthesis of the new 5,6-fused ring system are the formation of an amide intermediate followed by an intramolecular N-arylation reaction via nucleophilic aromatic substitution.

引用

页码：8721 / 8727

页数：7

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