Phosphine(III)-Triggered One-Pot Domino Sequences towards 5,6-Dihydropyridine-2-(1H)-One and Pyridine-2(1H)-One Scaffolds

被引：1
|
作者：
Makra, Zsofia [1 ]
Madacsi, Ramona [1 ]
Martinek, Tamas A. [2 ]
Benyei, Attila [3 ]
Puskas, Laszlo G. [1 ]
Gyuris, Mario [1 ]
Kanizsai, Ivan [1 ]
机构：
[1] AVIDIN Ltd, Also Kikoto Sor 11-D, H-6726 Szeged, Hungary
[2] Univ Szeged, Dept Med Chem, Dom Ter 8, H-6720 Szeged, Hungary
[3] Univ Debrecen, Dept Phys Chem, Lab Xray Diffract, Egyet Ter 1, H-4032 Debrecen, Hungary
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 06期
关键词：
Phosphine(III); One-pot domino synthesis; Mannich precursor; 5; 6-Dihydropyridine-2(1H)-one; Pyridine-2(1H)-one; BAYLIS-HILLMAN REACTION; VINYLOGOUS ALDOL REACTION; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED REACTION; ACRYLAMIDE; PHOSPHINE; DERIVATIVES; DIHYDROPYRIDINONE; ENHANCEMENT;
D O I：
10.1002/adsc.202101370
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An elegant P(nBu)(3)-triggered synthetic approach has been developed towards multisubstituted 5,6-dihydropyridin-2(1H)-one and pyridin-2(1H)-one derivatives exploiting a domino process involving retro-Claisen/intra-MBH/Wittig/vinylogous aldol transformations as well as retro-Claisen/intra-MBH/ylide hydrolysis/oxidation sequences. This transformation demonstrates chemo- and regioselectivity as well as accessible high diversity enchancement in 17-90% isolated yield.
引用
收藏
页码：1134 / 1143
页数：10
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