Phosphine(III)-Triggered One-Pot Domino Sequences towards 5,6-Dihydropyridine-2-(1H)-One and Pyridine-2(1H)-One Scaffolds

被引：1

作者：

Makra, Zsofia ^{[1
]}

Madacsi, Ramona ^{[1
]}

Martinek, Tamas A. ^{[2
]}

Benyei, Attila ^{[3
]}

Puskas, Laszlo G. ^{[1
]}

Gyuris, Mario ^{[1
]}

Kanizsai, Ivan ^{[1
]}

机构：

[1] AVIDIN Ltd, Also Kikoto Sor 11-D, H-6726 Szeged, Hungary

[2] Univ Szeged, Dept Med Chem, Dom Ter 8, H-6720 Szeged, Hungary

[3] Univ Debrecen, Dept Phys Chem, Lab Xray Diffract, Egyet Ter 1, H-4032 Debrecen, Hungary

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 06期

关键词：

Phosphine(III); One-pot domino synthesis; Mannich precursor; 5; 6-Dihydropyridine-2(1H)-one; Pyridine-2(1H)-one; BAYLIS-HILLMAN REACTION; VINYLOGOUS ALDOL REACTION; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED REACTION; ACRYLAMIDE; PHOSPHINE; DERIVATIVES; DIHYDROPYRIDINONE; ENHANCEMENT;

D O I：

10.1002/adsc.202101370

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An elegant P(nBu)(3)-triggered synthetic approach has been developed towards multisubstituted 5,6-dihydropyridin-2(1H)-one and pyridin-2(1H)-one derivatives exploiting a domino process involving retro-Claisen/intra-MBH/Wittig/vinylogous aldol transformations as well as retro-Claisen/intra-MBH/ylide hydrolysis/oxidation sequences. This transformation demonstrates chemo- and regioselectivity as well as accessible high diversity enchancement in 17-90% isolated yield.

引用

页码：1134 / 1143

页数：10

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