Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight

被引：12

作者：

Slama, Remy ^{[1
,4
]}

Grabsch, Carolin ^{[2
]}

Lepeule, Johanna ^{[1
,4
]}

Siroux, Valerie ^{[1
,3
]}

Cyrys, Josef ^{[5
,6
]}

Sausenthaler, Stefanie ^{[5
]}

Herbarth, Olf ^{[7
]}

Bauer, Mario ^{[2
]}

Borte, Michael ^{[8
,9
]}

Wichmann, H. Erich ^{[5
]}

Heinrich, Joachim ^{[5
]}

机构：

[1] INSERM, F-38042 Grenoble, France

[2] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, D-04318 Leipzig, Germany

[3] Univ Grenoble 1, U823, Team Epidemiol Canc & Severe Dis, Inst Albert Bonniot, F-38042 Grenoble, France

[4] Univ Grenoble 1, Avenir Team, U823, Inst Albert Bonniot, F-38042 Grenoble, France

[5] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, D-85763 Neuherberg, Germany

[6] Univ Augsburg, Ctr Environm Sci, D-86159 Augsburg, Germany

[7] Univ Leipzig, Fac Med, Dept Environm Med & Hyg, Leipzig, Germany

[8] Univ Leipzig, Dept Paediat, Leipzig, Germany

[9] Municipal Hosp St Georg, Leipzig, Germany

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 30卷 / 04期

关键词：

Air pollution; Birth weight; Particulate matter; Passive smoking; Polymorphism; Genetic; Smoking; ENVIRONMENTAL TOBACCO-SMOKE; AMBIENT AIR-POLLUTION; POPULATION STRATIFICATION; PREGNANCY OUTCOMES; RESPIRATORY HEALTH; COHORT; GSTM1; LUNG; IDENTIFICATION; EXPRESSION;

D O I：

10.1016/j.reprotox.2010.07.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM2 5) on offspring birth weight Among newborns from LISA cohort we tested if polymorphisms of GSTT1 GSTP1 GSTM1 and CYP2D6 genes modified the effect measure of PM2 5 on term birth weight Subsequently we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking) PM2 5 exposure above the median value (reference below) was associated with birth weight changes by 76 g in the homozygous wild type genotype (n = 161) -90 g in the heterozygous genotype (n = 154) and 168 g in children with GSTP1 *1B/*1B mutant genotype (n = 39 interaction test p = 0 05) No effect measure modification with PM2 5 was detected for GSTT1 GSTM1 or CYP2D6 polymorphisms (p >= 0 12) No effect measure modification with GSTP1 polymorphism was detected for active (p = 0 71) nor for passive smoking effects on birth weight (p = 0 13) (C) 2010 Elsevier Inc All rights reserved

引用

页码：600 / 612

页数：13

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