Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones

被引：4
|
作者：
Wang, Cece [1 ]
Zhou, Lu [1 ]
Qiu, Jian [1 ]
Yang, Kai [1 ]
Song, Qiuling [1 ,2 ]
机构：
[1] Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fujian Prov Univ, Fuzhou 350108, Fujian, Peoples R China
[2] Huaqiao Univ, Inst Next Generat Matter Transformat, Coll Mat Sci Engn, 668 Jimei Blvd, Xiamen 361021, Fujian, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 04期
基金：
中国国家自然科学基金;
关键词：
AZA-BENZOIN REACTIONS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; RH(I)-CATALYZED ADDITION; EFFICIENT SYNTHESIS; 1,2-AMINO ALCOHOLS; ALDEHYDES; HYDROGENATION; DERIVATIVES; ACCESS;
D O I：
10.1039/d1qo01721g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we present a diastereoselective addition of arylboronic acids to alpha-keto N-tert-butanesulfinyl aldimines catalyzed by a Rh(i) catalyst. This reaction provides a practical method to obtain valuable chiral alpha-amino ketones with excellent diastereoselectivity, featuring operational simplicity, mild reaction conditions and a broad substrate scope.
引用
收藏
页码：1016 / 1022
页数：7
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