Water-soluble propofol analogues with intravenous anaesthetic activity

被引：12
|
作者：
Cooke, A [1 ]
Anderson, A
Buchanan, K
Byford, A
Gemmell, D
Hamilton, N
McPhail, P
Miller, S
Sundaram, H
Vijn, P
机构：
[1] Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland
[2] Organon Labs Ltd, Dept Pharmacol, Newhouse ML1 5SH, Scotland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 07期
关键词：
D O I：
10.1016/S0960-894X(01)00088-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：927 / 930
页数：4
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