Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron

被引：56

作者：

Zhou, Mingkang ^{[1
]}

Li, Kaidi ^{[1
]}

Chen, Dongping ^{[1
]}

Xu, Ronghua ^{[1
]}

Xu, Guangqing ^{[1
,2
]}

Tang, Wenjun ^{[1
,2
,3
]}

机构：

[1] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] NingBo Zejun Pharmaceut Technol Co Ltd, Ningbo 315336, Peoples R China

[3] Univ Chinese Acadclny Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 23期

关键词：

ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; VICINAL DIAMINES; BORONIC ESTERS; CATALYSIS; ISOQUINOLINES; EPOXIDATION; DIBORATION; BORYLATION; COMPLEXES;

D O I：

10.1021/jacs.0c04558

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.

引用

页码：10337 / 10342

页数：6

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