Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities

被引：52

作者：

Zhang, Jing-Jing ^{[1
]}

Che, Chi-Ming ^{[2
,3
]}

Ott, Ingo ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany

[2] Univ Hong Kong, State Key Lab Synthet Chem, Chem Biol Ctr, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2015年 / 782卷

关键词：

Anti-cancer activity; Platinum(II) carbene complexes; N-heterocyclic carbene (NHC); Caffeine; IN-VITRO; DNA-BINDING; HELA-CELLS; DIFFERENTIATION; LIGANDS; CYTOTOXICITY; ANGIOGENESIS; REACTIVITY;

D O I：

10.1016/j.jorganchem.2014.10.041

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organometallic platinum(II) terpyridine complexes with a caffeine derived N-heterocyclic carbene (NHC) ligand were investigated as possible anti-cancer drugs in comparison to analogs, which contain N-coordinated theobromine. In general the carbene complexes displayed significantly higher biological activity than the theobromine analogs. In particular, the caffeine derived organometallic platinum(II) complex [PtII(2,20: 60,200-terpyridine) (1,3,7,9-tetramethylxanthine-8-ylidene)](PF6) 2 (1) displayed very promising cytotoxic activity towards several cancer cell lines, and showed in-vitro anti-angiogenic effects at sub-cytotoxic concentrations. Moreover, it induced neural differentiation-like morphological changes in breast adenocarcinoma (MCF-7) cells. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：37 / 41

页数：5

共 50 条

[21] On the Bonding in N-Heterocyclic Carbene Complexes of Germanium(II)
Ruddy, Adam J.
Rupar, Paul A.
Bladek, Kamila J.
Allan, Christopher J.
Avery, Jessica C.
Baines, Kim M.
[J]. ORGANOMETALLICS, 2010, 29 (06) : 1362 - 1367
[22] Hydroamination of Unactivated Alkenes Catalyzed by Novel Platinum(II) N-Heterocyclic Carbene Complexes
Cao, Peng
Cabrera, Jose
Padilla, Robin
Serra, Daniel
Rominger, Frank
Limbach, Michael
[J]. ORGANOMETALLICS, 2012, 31 (03) : 921 - 929
[23] N-heterocyclic carbene Pt(II) complexes from caffeine: synthesis, structures and photoluminescent properties
Hu, Jian Jin
Bai, Shi-Qiang
Yeh, Hsiu Hsuan
Young, David J.
Chi, Yun
Hor, T. S. Andy
[J]. DALTON TRANSACTIONS, 2011, 40 (17) : 4402 - 4406
[24] Pyridine derived N-heterocyclic carbene complexes of platinum: Synthesis, structure and ligand substitution kinetics
Owen, JS
Bercaw, JE
Labinger, JA
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U13 - U13
[25] Synthesis and Study of Palladium(II) and Platinum(II) Complexes Supported by a Common "Wingtip" N-Heterocyclic Carbene
Dinda, Joydev
Jhulki, Lalmohan
Kisan, Hemanta K.
Mahapatra, Pradip K.
Isab, Anvarhusein A.
Bielawski, Christopher W.
[J]. CHEMISTRYSELECT, 2018, 3 (38): : 10732 - 10737
[26] Palladium(II) and Platinum(II) Complexes Featuring a Nitrile-Functionalized N-Heterocyclic Carbene Ligand
O, Wylie W. N.
Lough, Alan J.
Morris, Robert H.
[J]. ORGANOMETALLICS, 2010, 29 (03) : 570 - 581
[27] Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug
Sharhan, Olla
Heidelberg, Thorsten
Hashim, Najihah Mohd
Al-Madhagi, Wafa M.
Ali, Hapipah Mohd
[J]. INORGANICA CHIMICA ACTA, 2020, 504
[28] Palladium(II)-N-heterocyclic carbene complexes derived from proline: synthesis and characterization
Tang, Yi-Qiang
Lu, Jian-Mei
Wang, Xiu-Ren
Shao, Li-Xiong
[J]. TETRAHEDRON, 2010, 66 (40) : 7970 - 7974
[29] T-Shaped Platinum(II) Complexes Stabilised by Bulky N-Heterocyclic Carbene Ligands
Rivada-Wheelaghan, Orestes
Donnadieu, Bruno
Maya, Celia
Conejero, Salvador
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (34) : 10323 - 10326
[30] Synthesis of N-heterocyclic carbene boranes via silver N-heterocyclic carbene complexes
Ono, Shintaro
Watanabe, Takashi
Nakamura, Yosuke
Sato, Hiroyasu
Hashimoto, Toru
Yamaguchi, Yoshitaka
[J]. POLYHEDRON, 2017, 137 : 296 - 305

← 1 2 3 4 5 →