Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities

被引：52
|
作者：
Zhang, Jing-Jing [1 ]
Che, Chi-Ming [2 ,3 ]
Ott, Ingo [1 ]
机构：
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany
[2] Univ Hong Kong, State Key Lab Synthet Chem, Chem Biol Ctr, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2015年 / 782卷
关键词：
Anti-cancer activity; Platinum(II) carbene complexes; N-heterocyclic carbene (NHC); Caffeine; IN-VITRO; DNA-BINDING; HELA-CELLS; DIFFERENTIATION; LIGANDS; CYTOTOXICITY; ANGIOGENESIS; REACTIVITY;
D O I：
10.1016/j.jorganchem.2014.10.041
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Organometallic platinum(II) terpyridine complexes with a caffeine derived N-heterocyclic carbene (NHC) ligand were investigated as possible anti-cancer drugs in comparison to analogs, which contain N-coordinated theobromine. In general the carbene complexes displayed significantly higher biological activity than the theobromine analogs. In particular, the caffeine derived organometallic platinum(II) complex [PtII(2,20: 60,200-terpyridine) (1,3,7,9-tetramethylxanthine-8-ylidene)](PF6) 2 (1) displayed very promising cytotoxic activity towards several cancer cell lines, and showed in-vitro anti-angiogenic effects at sub-cytotoxic concentrations. Moreover, it induced neural differentiation-like morphological changes in breast adenocarcinoma (MCF-7) cells. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：37 / 41
页数：5
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