Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings

被引：21

作者：

Abdelraheem, Eman M. M. ^{[1
,2
]}

Madhavachary, Rudrakshula ^{[1
]}

Rossetti, Arianna ^{[1
]}

Kurpiewska, Katarzyna ^{[3
]}

Kalinowska-Tluscik, Justyna ^{[3
]}

Shaabani, Shabnam ^{[1
]}

Domling, Alexander ^{[1
]}

机构：

[1] Univ Groningen, Dept Drug Design, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[2] Sohag Univ, Chem Dept, Fac Sci, Sohag 82524, Egypt

[3] Jagiellonian Univ, Fac Chem, Gronostajowa 2, PL-30387 Krakow, Poland

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 22期

关键词：

MACROCYCLES;

D O I：

10.1021/acs.orglett.7b03094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8-11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope

引用

页码：6176 / 6179

页数：4

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