Impact of various factors on radioactivity distribution in different DBS papers

被引：22
|
作者：
Ren, Xiao [1 ]
Paehler, Tobias [2 ]
Zimmer, Manfred [2 ]
Guo, Zuyu [1 ]
Zane, Patricia [1 ]
Emmons, Gary T. [1 ]
机构：
[1] Sanofi Aventis, Safety & Anim Res, Drug Disposit, Bridgewater, NJ USA
[2] Sanofi Aventis, Safety & Anim Res, Drug Disposit, Frankfurt, Germany
来源：
BIOANALYSIS | 2010年 / 2卷 / 08期
关键词：
DRIED BLOOD SPOTS;
D O I：
10.4155/BIO.10.96
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Dried blood spot (DBS) sampling could potentially become the preferred blood collection technique in toxicological and clinical studies. Autoradiography was performed to study compound distribution within a DBS under different conditions using five papers, 3IETF, Grade 226, 903 (R), FTA (R) and FTA (R) Elute. Results: The results showed an uneven distribution in all papers with common distribution patterns regardless of compounds: decreased concentrations along the edge, the volcano effect in the middle and the speckle pattern in the center. Treated papers were more readily influenced by environmental factors. Conclusion: Autoradiography enables visualization of a compound's distribution and can guide bioanalytical assay development by allowing convenient evaluation of factors, such as choice of paper, spotting volume, punch size, punch location, temperature and humidity.
引用
收藏
页码：1469 / 1475
页数：7
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