Structure-based design of a protein-protein interaction inhibitor, ABT-263, for the treatment of cancer

被引：0
|
作者：
Wendt, Michael D. [1 ]
机构：
[1] Abbott Labs, Global Pharmaceut R&D, Canc Res, Abbott Pk, IL 60064 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 238卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
246-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Correction to: The design and development of covalent protein-protein interaction inhibitors for cancer treatment
    Sha-Sha Cheng
    Guan-Jun Yang
    Wanhe Wang
    Chung-Hang Leung
    Dik-Lung Ma
    Journal of Hematology & Oncology, 13
  • [32] Structure-Based Approaches for Protein-Protein Interaction Prediction Using Machine Learning and Deep Learning
    Kiouri, Despoina P.
    Batsis, Georgios C.
    Chasapis, Christos T.
    BIOMOLECULES, 2025, 15 (01)
  • [33] Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction
    Chessari, Gianni
    Hardcastle, Ian R.
    Ahn, Jong Sook
    Anil, Burcu
    Anscombe, Elizabeth
    Bawn, Ruth H.
    Bevan, Luke D.
    Blackburn, Timothy J.
    Buck, Ildiko
    Cano, Celine
    Carbain, Benoit
    Castro, Juan
    Cons, Ben
    Cully, Sarah J.
    Endicott, Jane A.
    Fazal, Lynsey
    Golding, Bernard T.
    Griffin, Roger J.
    Haggerty, Karen
    Harnor, Suzannah J.
    Hearn, Keisha
    Hobson, Stephen
    Holvey, Rhian S.
    Howard, Steven
    Jennings, Claire E.
    Johnson, Christopher N.
    Lunec, John
    Miller, Duncan C.
    Newell, David R.
    Noble, Martin E. M.
    Reeks, Judith
    Revill, Charlotte H.
    Riedinger, Christiane
    St Denis, Jeffrey D.
    Tamanini, Emiliano
    Thomas, Huw
    Thompson, Neil T.
    Vinkovic, Mladen
    Wedge, Stephen R.
    Williams, Pamela A.
    Wilsher, Nicola E.
    Zhang, Bian
    Zhao, Yan
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (07) : 4071 - 4088
  • [34] Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions
    Krueger, Dennis M.
    Glas, Adrian
    Bier, David
    Pospiech, Nicole
    Wallraven, Kerstin
    Dietrich, Laura
    Ottmann, Christian
    Koch, Oliver
    Hennig, Sven
    Grossmann, Tom N.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (21) : 8982 - 8988
  • [35] Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells
    Cai, Gongli
    Bao, Yishu
    Li, Qingyun
    Hsu, Pang-Hung
    Xia, Jiang
    Ngo, Jacky Chi Ki
    COMMUNICATIONS CHEMISTRY, 2024, 7 (01):
  • [36] The Bcl-2 family protein inhibitor, ABT-263, broadly potentiates the cytotoxicity of multiple therapeutic agents in vitro and in vivo
    Tse, C.
    Chen, J.
    Jin, S.
    Abraham, V.
    Nimmer, P.
    Tahir, S.
    Smith, M.
    Zhang, H.
    Rosenberg, S.
    Elmore, S.
    EJC SUPPLEMENTS, 2008, 6 (12): : 85 - 85
  • [37] Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction
    Sillerud, LO
    Larson, RS
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2005, 6 (02) : 151 - 169
  • [38] The Bcl-2 family protein inhibitor, ABT-263, promotes apoptotic-like response in isolated platelets.
    Tse, Chris
    Zhang, Haichao
    Chen, Jun
    Fryer, Ryan M.
    Nelson, Richard
    Nimmer, Paul
    Reinhart, Glenn A.
    Smith, Morey L.
    Tahir, Stephen K.
    Rosenberg, Saul H.
    Elmore, Steven W.
    Hagey, Anne E.
    BLOOD, 2006, 108 (11) : 333A - 333A
  • [39] Computational Investigation of SENP:SUMO Protein-Protein Interaction for Structure Based Drug Design
    Kumar, Ashutosh
    Zhang, Kam Y. J.
    MOLECULAR INFORMATICS, 2013, 32 (03) : 267 - 280
  • [40] Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors
    Wisniewski, John A.
    Yin, Jinya
    Teuscher, Kevin B.
    Zhang, Min
    Ji, Haitao
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (05): : 508 - 513
12345