A general synthesis of aromatic amides via palladium-catalyzed direct aminocarbonylation of aryl chlorides

被引：9

作者：

Wang, Peng ^{[1
]}

Yang, Ji ^{[1
]}

Sun, Kangkang ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 09期

关键词：

REDUCTIVE AMINOCARBONYLATION; MULTICOMPONENT SYNTHESIS; ZEROVALENT PALLADIUM; COUPLING REACTIONS; CARBONYLATION; HALIDES; BROMIDES; IODIDES; ESTERS;

D O I：

10.1039/d2qo00251e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct palladium-catalyzed selective carbonylative coupling of less reactive aryl chlorides (including electron-rich, -neutral and -deficient ones) with primary and secondary aliphatic and aromatic amines is described for the first time. Key for the success of this transformation is the use of a palladium/Xantphos catalyst system in the presence of cesium chloride (CsCl) as additive. In general, this catalytic system allows for efficient conversion of diverse aryl chlorides with an array of amines and with good functional group compatibility (60 examples, conversion up to 99%, isolated yield up to 95%).

引用

页码：2491 / 2497

页数：7

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