Novel taxane diterpenoids from Taiwanese yew trees

被引：4
|
作者：
Shen, YC [1 ]
Chang, YT [1 ]
Wang, SS [1 ]
Pan, YL [1 ]
Lo, KL [1 ]
Lin, YC [1 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 80424, Taiwan
来源：
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 2003年 / 22卷 / 04期
关键词：
taxane diterpenes; Taxus mairei; T; sumatrana; antitumor agents; cytotoxicity;
D O I：
10.1081/TXR-120026912
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Recent discovery of new and bioactive taxane diterpenoids from the roots, barks, seeds, leaves and the stems of Taxus mairei and T. sumatrana, Taiwanese yew trees are described. More than thirty new compounds including taxumatrols A and B (36, 37) have been isolated and their structures determined by spectroscopic analysis and chemical derivatization and correlation. Some of the isolated taxoids exhibited potent cytotoxicity against human tumor cells.
引用
收藏
页码：533 / 545
页数：13
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