Pd/C-Catalyzed Synthesis of Isoquinolones through C-H Activation

被引：33

作者：

Shu, Zhen ^{[1
]}

Li, Wei ^{[1
]}

Wang, Baiquan ^{[1
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Key Lab Adv Energy Mat Chem, State Key Lab Elementoorgan Chem,Coll Chem,Minist, Tianjin 300071, Peoples R China

来源：

CHEMCATCHEM | 2015年 / 7卷 / 04期

基金：

中国国家自然科学基金;

关键词：

alkynes; CH activation; heterogeneous catalysis; palladium; synthetic methods; CROSS-COUPLING REACTION; ONE-POT SYNTHESIS; LIGAND-FREE; MEDIATED SYNTHESIS; BOND FORMATION; REGIOSELECTIVE SYNTHESIS; BETA-PHENYLETHYLAMINES; OXIDATIVE ANNULATION; PALLADIUM CATALYSTS; HETEROGENEOUS PD/C;

D O I：

10.1002/cctc.201403059

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The direct synthesis of isoquinolones from benzamides and alkynes through CH activation was developed by using Pd/C as a heterogeneous catalyst without a ligand under mild conditions. A variety of isoquinolones were obtained in good yields with excellent regioselectivities. The Pd/C catalyst could be recycled three times without a significant decrease in the activity (yields as high as 85%).

引用

页码：605 / 608

页数：4

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