Efficient and Chemoselective Amidation of β-Carboline Carboxylic Acids

被引：4
|
作者：
Lin, Miaoman [1 ]
Liang, Weida [1 ]
Ma, Jiale [1 ]
Wu, Ye [1 ]
Xiao, Xiao [2 ]
Ying, Jianxi [3 ]
Yan, Yinghua [1 ]
Zhao, Lingling [1 ]
Jin, Haixiao [4 ]
Liang, Hongze [1 ]
Cui, Wei [2 ]
Yan, Xiaojun [4 ]
机构：
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Dept Chem, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Ningbo Key Lab Behav Neurosci, Zhejiang Prov Key Lab Pathophysiol, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
[3] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China
[4] Ningbo Univ, Coll Food & Pharmaceut Sci, Ningbo 315211, Zhejiang, Peoples R China
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 44期
基金：
中国国家自然科学基金;
关键词：
Amidation; beta-Carboline; Fascaplysin; HBTU; Neuroprotection; MARINE NATURAL-PRODUCTS; AMIDE BOND FORMATION; ALKALOID FASCAPLYSIN; BIOLOGICAL-ACTIVITY; DESIGN; CHEMISTRY;
D O I：
10.1002/slct.201903444
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of beta-carboline amides has been synthesized in one-pot reaction via coupling between an acid and an amine in the presence of HBTU/Et3N. This mild amidation reaction undergoes efficiently and chemoselectively. Bioactivity studies indicate that the beta-carboline amide derivatives exhibit neuroprotective activity and might be developed to be lead compounds for anti-stroke agents.
引用
收藏
页码：12978 / 12982
页数：5
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