Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

被引：71

作者：

Takashita, Emi ^{[1
]}

Kawakami, Chiharu ^{[2
]}

Morita, Hiroko ^{[1
]}

Ogawa, Rie ^{[1
]}

Fujisaki, Seiichiro ^{[1
]}

Shirakura, Masayuki ^{[1
]}

Miura, Hideka ^{[1
]}

Nakamura, Kazuya ^{[1
]}

Kishida, Noriko ^{[1
]}

Kuwahara, Tomoko ^{[1
]}

Mitamura, Keiko ^{[3
]}

Abe, Takashi ^{[4
]}

Ichikawa, Masataka ^{[5
]}

Yamazaki, Masahiko ^{[6
]}

Watanabe, Shinji ^{[1
]}

Odagiri, Takato ^{[1
]}

Komagome, Rika ^{[7
]}

Ohnishi, Asami ^{[8
]}

Tsutsui, Rika ^{[9
]}

Takahashi, Masaki ^{[10
]}

Sasaki, Mie ^{[11
]}

Tamura, Shiho ^{[12
]}

Shibata, Chihiro ^{[13
]}

Tanaka, Shizuka ^{[14
]}

Saito, Nozomi ^{[15
]}

Hirokawa, Chika ^{[16
]}

Yamamoto, Kazunari ^{[17
]}

Saito, Aoi ^{[18
]}

Kushibuchi, Izumi ^{[19
]}

Kataoka, Shunsuke ^{[20
]}

Tsukagoshi, Hiroyuki ^{[21
]}

Suzuki, Noriko ^{[22
]}

Uno, Yuka ^{[23
]}

Hashimoto, Hiroyuki ^{[24
]}

Nishikawa, Wakako ^{[25
]}

Nagashima, Mami ^{[26
]}

Watanabe, Sumi ^{[27
]}

Shimizu, Hideaki ^{[28
]}

Amano, Hazime ^{[29
]}

Arakawa, Sayoko ^{[30
]}

Oonuma, Masayuki ^{[31
]}

Takeuchi, Michiko ^{[32
]}

Okamura, Yuichiro ^{[33
]}

Sakai, Yukiko ^{[34
]}

Maehata, Takaharu ^{[35
]}

Furuta, Toshihiko ^{[36
]}

Yoneda, Tetsuya ^{[37
]}

Kodama, Hiroe ^{[38
]}

Sato, Kaori ^{[39
]}

Nishioka, Masahiro ^{[40
]}

机构：

[1] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo, Japan

[2] Yokohama City Inst Publ Hlth, Yokohama, Kanagawa, Japan

[3] Eiju Gen Hosp, Tokyo, Japan

[4] Abe Childrens Clin, Ichikawa, Kanagawa, Japan

[5] Ichikawa Childrens Clin, Ichikawa, Kanagawa, Japan

[6] Zama Childrens Clin, Zama, Kanagawa, Japan

[7] Hokkaido Inst Publ Hlth, Sapporo, Hokkaido, Japan

[8] Sapporo City Inst Publ Hlth, Sapporo, Hokkaido, Japan

[9] Aomori Prefectural Publ Hlth & Environm Ctr, Aomori, Japan

[10] Iwate Prefectural Res Inst Environm Sci & Publ Hl, Takizawa, Iwate, Japan

[11] Miyagi Prefectural Inst Publ Hlth & Environm, Sendai, Miyagi, Japan

[12] Sendai City Inst Publ Hlth, Sendai, Miyagi, Japan

[13] Akita Prefectural Res Ctr Publ Hlth & Environm, Akita, Japan

[14] Yamagata Prefectural Inst Publ Hlth, Yamagata, Japan

[15] Fukushima Prefectural Inst Publ Hlth, Fukushima, Japan

[16] Niigata Prefectural Inst Publ Hlth & Environm Sci, Niigata, Japan

[17] Niigata City Inst Publ Hlth & Environm, Niigata, Japan

[18] Ibaraki Prefectural Inst Publ Hlth, Ibaraki, Japan

[19] Tochigi Prefectural Inst Publ Hlth & Environm Sci, Kawachi, Tochigi, Japan

[20] Utsunomiya City Inst Publ Hlth & Environm Sci, Utsunomiya, Tochigi, Japan

[21] Gunma Prefectural Inst Publ Hlth & Environm Sci, Gunma, Japan

[22] Saitama Inst Publ Hlth, Wako, Saitama, Japan

[23] Saitama City Inst Hlth Sci & Res, Saitama, Japan

[24] Chiba Prefectural Inst Publ Hlth, Chiba, Japan

[25] Chiba City Inst Hlth & Environm, Chiba, Japan

[26] Tokyo Metropolitan Inst Publ Hlth, Tokyo, Japan

[27] Kanagawa Prefectural Inst Publ Hlth, Yokohama, Kanagawa, Japan

[28] Kawasaki City Inst Hlth, Kawasaki, Kanagawa, Japan

[29] Yokosuka Inst Publ Hlth, Yokosuka, Kanagawa, Japan

[30] Sagamihara City Inst Publ Hlth, Sagamihara, Kanagawa, Japan

[31] Yamanashi Inst Publ Hlth, Kofu, Yamanashi, Japan

[32] Nagano Environm Conservat Res Inst, Nagano, Japan

[33] Nagano City Hlth Ctr, Nagano, Japan

[34] Shizuoka Inst Environm & Hyg, Shizuoka, Japan

[35] Shizuoka City Inst Environm Sci & Publ Hlth, Shizuoka, Japan

[36] Hamamatsu City Hlth Environm Res Ctr, Hamamatsu, Shizuoka, Japan

[37] Toyama Inst Hlth, Toyama, Japan

[38] Ishikawa Prefectural Inst Publ Hlth & Environm Sc, Kanazawa, Ishikawa, Japan

[39] Fukui Prefectural Inst Publ Hlth & Environm Sci, Fukui, Japan

[40] Gifu Prefectural Res Inst Hlth & Environm Sci, Gifu, Japan

[41] Gifu Municipal Inst Publ Hlth, Gifu, Japan

[42] Aichi Prefectural Inst Publ Hlth, Nagoya, Aichi, Japan

[43] Mie Prefecture Hlth & Environm Res Inst, Tsu, Mie, Japan

[44] Shiga Prefectural Inst Publ Hlth, Otsu, Shiga, Japan

[45] Kyoto Prefectural Inst Publ Hlth & Environm, Kyoto, Japan

[46] Kyoto City Inst Hlth & Environm Sci, Kyoto, Japan

[47] Osaka Inst Publ Hlth, Osaka, Japan

[48] Sakai City Inst Publ Hlth, Sakai, Osaka, Japan

[49] Hyogo Prefectural Inst Publ Hlth & Consumer Sci, Kobe, Hyogo, Japan

[50] Kobe Inst Hlth, Kobe, Hyogo, Japan

来源：

EUROSURVEILLANCE | 2019年 / 24卷 / 03期

关键词：

D O I：

10.2807/1560-7917.ES.2019.24.3.1800698

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in December 2018. This mutation is known to confer reduced susceptibility to baloxavir, and the two mutant viruses exhibited 76- and 120-fold reduced susceptibility to baloxavir.

引用

页码：18 / 22

页数：5

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