Intra-Articular Leukocyte-Rich Platelet-Rich Plasma versus Intra-Articular Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 14 Randomized Controlled Trials

被引:9
|
作者
Peng, Yu-Ning [1 ]
Chen, Jean-Lon [1 ]
Hsu, Chih-Chin [2 ]
Chen, Carl P. C. [1 ]
Suputtitada, Areerat [3 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept Phys Med & Rehabil, Coll Med, Taoyuan City 33343, Taiwan
[2] Chang Gung Univ, Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, Coll Med, Taoyuan City 33343, Taiwan
[3] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Dept Rehabil Med, Bangkok 10330, Thailand
关键词
knee; osteoarthritis; leukocyte-rich platelet-rich plasma; leukocyte-poor platelet-rich plasma; hyaluronic acid; DOUBLE-BLIND; CLINICAL-OUTCOMES; PRP INJECTIONS; VISCOSUPPLEMENTATION; EFFICACY; SINGLE;
D O I
10.3390/ph15080974
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
(1) Background: To evaluate the clinical effects of leukocyte-rich platelet-rich plasma (LR-PRP) and hyaluronic acid (HA) injections in treating patients suffering from knee osteoarthritis (OA); (2) Methods: Randomized controlled trials (RCTs) were searched from PubMed, Web of Science, and Cochrane Library. Keywords were: platelet-rich plasma, LR-PRP, leukocyte-rich, hyaluronic acid, and knee osteoarthritis. The included RCTs were published between the 1st of November 2011 and the 3rd of February 2021. Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, visual analog scale (VAS) scores, International Knee Documentation Committee (IKDC) scores, and adverse events were used as outcomes for evaluation; (3) Results: A total of 14 RCTs were enrolled. At 6 months, revealed that the LR-PRP group was better than the HA group in WOMAC total, pain, and physical function scores. At 12 months, the LR-PRP group was better than the HA group in WOMAC stiffness and physical function scores. There was no significant difference in adverse events; (4) Conclusion: LR-PRP injection showed no significant pain relief effect as compared with HA injection. However, LR-PRP demonstrated better overall outcomes as compared to HA in knee OA patients at the follow-up periods of 3, 6, and 12 months. LR-PRP injection may be recommended as a feasible option in treating patients with knee OA.
引用
下载
收藏
页数:16
相关论文
共 50 条
  • [31] CONSENSUS STATEMENT ON INTRA-ARTICULAR INJECTIONS OF PLATELET-RICH PLASMA FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS
    Eymard, F.
    Ornetti, P.
    Maillet, J.
    Noel, E.
    Adam, P.
    Boyer, V. Legre
    Boyer, T.
    Allali, F.
    Bader, V. Gremeaux
    Kaux, J. F.
    Louati, K.
    Lamontagne, M.
    Michel, F.
    Richette, P.
    Bard, H.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1734 - 1734
  • [32] Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review
    Meheux, Carlos J.
    McCulloch, Patrick C.
    Lintner, David M.
    Varner, Kevin E.
    Harris, Joshua D.
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2016, 32 (03): : 495 - 505
  • [33] Use of Platelet-Rich Plasma in Intra-Articular Knee Injections for Osteoarthritis: A Systematic Review
    Lai, Lawrence P.
    Stitik, Todd P.
    Foye, Patrick M.
    Georgy, John S.
    Patibanda, Varun
    Chen, Boqing
    PM&R, 2015, 7 (06) : 637 - 648
  • [34] Comparison of Intra-articular Steroid and Platelet-Rich Plasma Injections in Patients With Knee Osteoarthritis
    Cinar, Cigdem
    Bagatir, Nazire
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (11)
  • [35] Cytokine Profiling and Intra-Articular Injection of Autologous Platelet-Rich Plasma in Knee Osteoarthritis
    Riewruja, Kanyakorn
    Phakham, Suphattra
    Sompolpong, Patlapa
    Reantragoon, Rangsima
    Tanavalee, Aree
    Ngarmukos, Srihatach
    Udomsinprasert, Wanvisa
    Suantawee, Tanyawan
    Dechsupa, Sinsuda
    Honsawek, Sittisak
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (02)
  • [36] Intra-articular hyaluronic acid for treatment of osteoarthritis of the knee
    Moskowitz, R
    Altman, R
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (12): : 1440 - 1441
  • [37] Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial
    Filardo, Giuseppe
    Di Matteo, Berardo
    Di Martino, Alessandro
    Merli, Maria Letizia
    Cenacchi, Annarita
    Fornasari, PierMaria
    Marcacci, Maurilio
    Kon, Elizaveta
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2015, 43 (07): : 1575 - 1582
  • [38] Efficacy of Ultrasound-guided Intra-articular Injections of Platelet-rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis
    Battaglia, Milva
    Guaraldi, Federica
    Vannini, Francesca
    Rossi, Giuseppe
    Timoncini, Antonio
    Buda, Roberto
    Giannini, Sandro
    ORTHOPEDICS, 2013, 36 (12) : E1501 - E1508
  • [39] Comparison of intra-articular hyaluronic acid and methylprednisolone for pain management in knee osteoarthritis: A meta-analysis of randomized controlled trials
    Ran, Jian
    Yang, Xiaohui
    Ren, Zheng
    Wang, Jian
    Dong, Hui
    INTERNATIONAL JOURNAL OF SURGERY, 2018, 53 : 103 - 110
  • [40] Intra-articular injection of platelet-rich plasma versus hyaluronic acid viscosupplementation in treating haemophilic arthropathy of the knee joints
    Li, Tsung-Ying
    Cheng, Shin-Nan
    Pan, Ru-Yu
    Chen, Yeu-Chin
    HAEMOPHILIA, 2016, 22 : 96 - 96