Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

被引：27

作者：

Zhang, Yu-Hui ^{[1
,2
]}

Zhang, Ying-Ming ^{[2
]}

Sheng, Xianliang ^{[1
]}

Wang, Jie ^{[1
]}

Liu, Yu ^{[2
,3
]}

机构：

[1] Inner Mongolia Agr Univ, Coll Sci, Hohhot 010018, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Dept Chem, Tianjin 300071, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 07期

关键词：

SILICA NANOPARTICLES; CANCER; DELIVERY; PRODRUG; THERANOSTICS; DIAGNOSTICS; MICELLES; VESICLES; REDOX;

D O I：

10.1039/c9cc08491f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and beta-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.

引用

页码：1042 / 1045

页数：4

共 36 条

[21] Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release
Gao, Lingyan
Zheng, Bo
Chen, Wei
Schalley, Christoph A.
CHEMICAL COMMUNICATIONS, 2015, 51 (80) : 14901 - 14904
[22] Construction and evaluation of biomass-modified mesoporous silica nanoparticles as enzyme-responsive and pH-Responsive drug carriers for the controlled release of quercetin
Li, Qi
Lai, Shisheng
Shang, Hongzhou
Qiao, Ning
Sun, Xiaoran
Lu, Yujin
Wang, Zimeng
Wang, Xinjing
Wu, Yi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2024, 98
[23] Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy
Zhang, Chengyuan
Pan, Dayi
Li, Jin
Hu, Jiani
Bains, Ashika
Guys, Nicholas
Zhu, Hongyan
Li, Xiaohui
Luo, Kui
Gong, Qiyong
Gu, Zhongwei
ACTA BIOMATERIALIA, 2017, 55 : 153 - 162
[24] Construction of hyperbranched polysiloxane-based multifunctional fluorescent prodrug for preferential cellular uptake and dual-responsive drug release
Zhao, Yan
Liu, Biao
Lou, Rui
Qi, Yibo
He, Miaomiao
Long, Sihao
Feng, Weixu
Yan, Hongxia
BIOMATERIALS ADVANCES, 2022, 137
[25] Enzyme-responsive supramolecular nanovalves crafted by mesoporous silica nanoparticles and choline-sulfonatocalix[4]arene [2]pseudorotaxanes for controlled cargo release
Sun, Yu-Long
Zhou, Yue
Li, Qing-Lan
Yang, Ying-Wei
CHEMICAL COMMUNICATIONS, 2013, 49 (79) : 9033 - 9035
[26] Temperature responsive fluorescent polymer nanoparticles (TRFNPs) for cellular imaging and controlled releasing of drug to living cells
Zhang, Ziang
Zhang, Di
Wei, Lin
Wang, Xi
Xu, Yueling
Li, Hung-Wing
Ma, Ming
Chen, Bo
Xiao, Lehui
COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 159 : 905 - 912
[27] Fluorescent polymeric assemblies as stimuli-responsive vehicles for drug controlled release and cell/tissue imaging
Chang, Ying
Li, Yang
Yu, Shirong
Mao, Jie
Liu, Cheng
Li, Qi
Yuan, Conghui
He, Ning
Luo, Weiang
Dai, Lizong
NANOTECHNOLOGY, 2015, 26 (02)
[28] Enzyme-Responsive Cell-Penetrating Peptide Conjugated Mesoporous Silica Quantum Dot Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells
Li, Jinming
Liu, Fang
Shao, Qing
Min, Yuanzeng
Costa, Marianne
Yeow, Edwin K. L.
Xing, Bengang
ADVANCED HEALTHCARE MATERIALS, 2014, 3 (08) : 1230 - 1239
[29] Stimuli-responsive conjugated polymer nanoparticles for cellular imaging and controlled-release drug delivery
Tuncel, Donus
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[30] Dendritic polymer prodrug-based unimolecular micelles for pH-responsive co-delivery of doxorubicin and camptothecin with synergistic controlled drug release effect
Chen, Wei
Liu, Peng
COLLOIDS AND SURFACES B-BIOINTERFACES, 2024, 238

← 1 2 3 4 →