Hyaluronic-acid-based β-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol

被引：22

作者：

Singh, Parbeen ^{[1
,2
]}

Wu, Li ^{[2
]}

Ren, Xiaohong ^{[2
]}

Zhang, Wei ^{[2
]}

Tang, Yan ^{[2
]}

Chen, Yongli ^{[1
]}

Carrier, Andrew ^{[3
,4
]}

Zhang, Xu ^{[1
,3
,4
]}

Zhang, Jiwen ^{[2
,5
]}

机构：

[1] Shenzhen Polytech, Postdoctoral Innovat Practice Base, Shenzhen 518055, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China

[3] Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[4] Cape Breton Univ, Dept Hlth Sci, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[5] Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 586卷

基金：

国家重点研发计划; 中国博士后科学基金;

关键词：

Solubility enhancement; Hyaluronic acid-beta-cyclodextrin grafted copolymer; alpha-Tocopherol; Inclusion complex; VITAMIN-E; INCLUSION COMPLEX; IN-VITRO; PHOTOSTABILITY; POLYMERS; MATS;

D O I：

10.1016/j.ijpharm.2020.119542

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with beta-cyclodextrin (beta-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system. Herein, different copolymers were prepared with varying HA:beta-CD ratios and characterized. VE loading capacity was directly correlated with increased beta-CD composition in the polymers and morphological changes were observed upon VE binding. The host materials and their VE inclusion complexes are not cytotoxic, and are thus useful for VE and drug delivery.

引用

页数：7

共 23 条

[21] Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2019, 137 : 227 - 232
[22] A water-soluble and biocompatible polymeric nanolabel based on naphthalimide grafted poly(acrylic acid) for the two-photon fluorescence imaging of living cells and C. elegans
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[23] A water-soluble and biocompatible polymeric nanolabel based on naphthalimide grafted poly(acrylic acid) for the two-photon fluorescence imaging of living cells and C. elegans (vol 148, pg 293, 2016)
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