The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

被引：17

作者：

Delrue, Charlotte ^{[1
]}

Speeckaert, Reinhart ^{[2
]}

Delanghe, Joris R. ^{[3
]}

Speeckaert, Marijn M. ^{[1
,4
]}

机构：

[1] Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Diagnost Sci, B-9000 Ghent, Belgium

[4] Res Fdn Flanders FWO, B-1000 Brussels, Belgium

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 02期

关键词：

diabetes mellitus; diabetic nephropathy; vitamin D; D-RECEPTOR GENE; SERUM 25-HYDROXYVITAMIN D; D-BINDING PROTEIN; D DEFICIENCY; KIDNEY-DISEASE; MICROVASCULAR COMPLICATIONS; PODOCYTE INJURY; D ANALOG; 1,25-DIHYDROXYVITAMIN D-3; ENDOTHELIAL FUNCTION;

D O I：

10.3390/ijms23020807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.

引用

页数：17

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