Characterization of unrelated clinical Legionella pneumophila isolates in Catalonia by monoclonal subgrouping and sequence-based typing

被引：5
|
作者：
Garcia-Nunez, Marian [1 ,2 ,3 ]
Quero, Sara [1 ,2 ,3 ]
Lluisa Pedro-Botet, Maria [1 ,2 ,3 ]
Barrabeig, Irene [4 ]
Avarez, Josep [4 ]
Campoy, Irene [1 ]
Rosa Sala, Maria [4 ]
Parraga-Nino, Noemi [1 ,2 ,3 ]
Minguell, Sofia [4 ]
Cayla, Joan [4 ,5 ]
Mateu, Lourdes [1 ,2 ,3 ]
Sabria, Miquel [1 ,2 ,3 ]
机构：
[1] Hosp Badalona Germans Trias & Pujol, Fundacio Inst Invest Germans Trias & Pujol, Infect Dis Unit, E-08916 Badalona, Spain
[2] Autonomous Univ Barcelona, Grp Estudio Legionelosis, E-08913 Cerdanyola Del Valles, Spain
[3] Ciber Enfermedades Resp, E-28029 Madrid, Spain
[4] Publich Hlth Agcy Catalonia, Epidemiol Surveillance, E-08005 Barcelona, Spain
[5] Ciber Salud Publ, E-28029 Madrid, Spain
来源：
FUTURE MICROBIOLOGY | 2016年 / 11卷 / 07期
关键词：
clinical isolates; Legionella; monoclonal antibody; sequence-based typing; COMMUNITY-ACQUIRED PNEUMONIA; LEGIONNAIRES-DISEASE; ANTIBODY SUBGROUPS; COOLING-TOWER; SEROGROUPS; LIPOPOLYSACCHARIDE; OUTBREAK; JAPAN; WATER; PERSISTENCE;
D O I：
10.2217/fmb-2016-0013
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. Methods: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. Results: The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions. Conclusion: L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.
引用
收藏
页码：865 / 875
页数：11
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