Traceless liquid-phase synthesis of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles on polyethylene glycol (PEG)

被引：6
|
作者：
Zong, YX [1 ]
Wang, JK [1 ]
Yue, GR [1 ]
Feng, L [1 ]
Song, ZE [1 ]
Song, H [1 ]
Han, YQ [1 ]
机构：
[1] Hexi Univ, Dept Chem, Key Lab Resources & Environm, Zhangye 73400, Peoples R China
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 31期
关键词：
poly(ethylene glycol) (PEG); 3-alkylamino-4,5-disubstituted-1,2.4-triazoles; arylacyl thiourea; benzoyl hydrazine; liquid-phase synthesis;
D O I：
10.1016/j.tetlet.2005.05.121
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A liquid-phase route to 3-alkylamino-4,5-disubstituted-1,2,4-triazoles has been developed, which permits the incorporation of three elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA/CH2Cl2. This method provided a library of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles with reasonable yields and excellent purity. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5139 / 5141
页数：3
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