Transmitter release deficits at the neuromuscular synapse of mice with mutations in the Cav2.1 (α1A) subunit of the P/Q-type Ca2+ channel

被引:7
|
作者
Plomp, JJ
Van Den Maagdenberg, AM
Ferrari, MD
Frants, RR
Molenaar, PC
机构
[1] Leiden Univ, Med Ctr, Dept Neurophysiol, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2300 RC Leiden, Netherlands
关键词
P/Q-type Ca2+ channel; neuromuscular junction (NMJ); mutation;
D O I
10.1196/annals.1254.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:29 / 32
页数:4
相关论文
共 50 条
  • [21] Isolation and functional characterization of the 5′-upstream region of mouse P/Q-type Ca2+ channel α1A subunit gene
    Takahashi, E
    Murata, Y
    Oki, T
    Miyamoto, N
    Mori, Y
    Takada, N
    Wanifuchi, H
    Wanifuchi, N
    Yagami, K
    Niidome, T
    Tanaka, I
    Katayama, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 260 (01) : 54 - 59
  • [22] Genetic Background Influences P/Q-type Ca2+ Channel α1A Subunit mRNA Expression in Olfactory Bulb and Reproductive Ability of N-type Ca2+ Channel α1B Subunit-Deficient Mice
    Eiki Takahashi
    Takeshi Nagasu
    Biochemical Genetics, 2005, 43 : 287 - 298
  • [23] Genetic background influences P/Q-type Ca2+ channel α1A subunit mRNA expression in olfactory bulb and reproductive ability of N-type Ca2+ channel α1B subunit-deficient mice
    Takahashi, E
    Nagasu, T
    BIOCHEMICAL GENETICS, 2005, 43 (5-6) : 287 - 298
  • [24] Lobe-specific calmodulin (CaM) regulation of P/Q-type (CaV2.1) Ca2+channels probed by CaM/channel fusion constructs
    Mori, MX
    Yue, DT
    BIOPHYSICAL JOURNAL, 2005, 88 (01) : 275A - 275A
  • [25] Alternative splicing of the Ca2+ channel β4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking
    Mich, Patrice M.
    Horne, William A.
    MOLECULAR PHARMACOLOGY, 2008, 74 (03) : 904 - 912
  • [26] P/Q-type Ca2+ channel α1A regulates synaptic competition on developing cerebellar Purkinje cells
    Miyazaki, T
    Hashimoto, K
    Shin, HS
    Kano, M
    Watanabe, M
    JOURNAL OF NEUROSCIENCE, 2004, 24 (07): : 1734 - 1743
  • [27] Construction of a high affinity dihydropyridine site in a P/Q-type Ca2+ channel α1 subunit.
    Hockerman, GH
    Peterson, BZ
    Sharp, EM
    Tanada, TN
    Scheuer, T
    Catterall, WA
    BIOPHYSICAL JOURNAL, 1998, 74 (02) : A107 - A107
  • [28] RGK GTPase-dependent CaV2.1 Ca2+ channel inhibition is independent of CaVβ-subunit-induced current potentiation
    Leyris, J. -P.
    Gondeau, C.
    Charnet, A.
    Delattre, C.
    Rousset, M.
    Cens, T.
    Charnet, P.
    FASEB JOURNAL, 2009, 23 (08): : 2627 - 2638
  • [29] Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant
    Alonso, Isabel
    Marques, Joana M.
    Sousa, Nuno
    Sequeiros, Jorge
    Olsson, I. Anna S.
    Silveira, Isabel
    NEUROBIOLOGY OF AGING, 2008, 29 (11) : 1733 - 1743
  • [30] Protein Kinase Cα and P-Type Ca2+ Channel CaV2.1 in Red Blood Cell Calcium Signalling
    Wagner-Britz, Lisa
    Wang, Jue
    Kaestner, Lars
    Bernhardt, Ingolf
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2013, 31 (06) : 883 - 891