Anticancer Activities of Some Novel Synthesized Thiazole and Thiohydantoin Derivatives

被引：0

作者：

Alahmadi, Yaser M. ^{[1
]}

Al-Thagfan, Sultan S. ^{[1
]}

Alolayan, Sultan O. ^{[1
]}

Al-Wasidi, Asma S. ^{[2
]}

Al-Jafshar, Nawal M. ^{[2
]}

Al-Anazi, Amal M. ^{[2
]}

Mohamad, Ali A. ^{[3
]}

Naglah, Ahmed M. ^{[4
,5
]}

机构：

[1] Taibah Univ, Coll Pharm, Clin & Hosp Pharm Dept, Madina Munawarah, Saudi Arabia

[2] Princess Nourah Bint Abdulrahman Univ, Dept Chem, Coll Sci, Riyadh 11671, Saudi Arabia

[3] Zagazig Univ, Invertebrate & Parasitol Dept, Fac Sci, Zagazig, Egypt

[4] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, DEDC, Riyadh 11451, Saudi Arabia

[5] Natl Res Ctr, Chem Ind Res Div, Peptide Chem Dept, Cairo 12622, Egypt

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 03期

关键词：

anticancer activities; cytotoxic activity; kinase assay; thiazole; thiohydantoin; CELLS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of new compounds carrying 1,3-thiazole and 2-thiohydantoin scaffold were synthesized and structurally confirmed by different spectroscopic methods such as IR, H-1-NMR, C-13-NMR and mass spectroscopy along with elemental analyses. All the synthesized compounds were examined for their cytotoxic activity versus HepG2 cell line. Compound 4 and its acetylated derivative showed the least IC50 values within the tested compounds. Additionally, compounds 4 and 6 were evaluated against VEGFR-2. The results revealed that compound 4 showed good VEGFR-2 inhibitory activity. Moreover, cell cycle analysis of compound 4 appeared cell cycle arrest at both G1 and G2/M phase of cell cycle profile of HepG2 cells.

引用

页码：541 / 546

页数：6

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