Anticancer Activities of Some Novel Synthesized Thiazole and Thiohydantoin Derivatives

被引：0
|
作者：
Alahmadi, Yaser M. [1 ]
Al-Thagfan, Sultan S. [1 ]
Alolayan, Sultan O. [1 ]
Al-Wasidi, Asma S. [2 ]
Al-Jafshar, Nawal M. [2 ]
Al-Anazi, Amal M. [2 ]
Mohamad, Ali A. [3 ]
Naglah, Ahmed M. [4 ,5 ]
机构：
[1] Taibah Univ, Coll Pharm, Clin & Hosp Pharm Dept, Madina Munawarah, Saudi Arabia
[2] Princess Nourah Bint Abdulrahman Univ, Dept Chem, Coll Sci, Riyadh 11671, Saudi Arabia
[3] Zagazig Univ, Invertebrate & Parasitol Dept, Fac Sci, Zagazig, Egypt
[4] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, DEDC, Riyadh 11451, Saudi Arabia
[5] Natl Res Ctr, Chem Ind Res Div, Peptide Chem Dept, Cairo 12622, Egypt
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 03期
关键词：
anticancer activities; cytotoxic activity; kinase assay; thiazole; thiohydantoin; CELLS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of new compounds carrying 1,3-thiazole and 2-thiohydantoin scaffold were synthesized and structurally confirmed by different spectroscopic methods such as IR, H-1-NMR, C-13-NMR and mass spectroscopy along with elemental analyses. All the synthesized compounds were examined for their cytotoxic activity versus HepG2 cell line. Compound 4 and its acetylated derivative showed the least IC50 values within the tested compounds. Additionally, compounds 4 and 6 were evaluated against VEGFR-2. The results revealed that compound 4 showed good VEGFR-2 inhibitory activity. Moreover, cell cycle analysis of compound 4 appeared cell cycle arrest at both G1 and G2/M phase of cell cycle profile of HepG2 cells.
引用
收藏
页码：541 / 546
页数：6
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