Urinary excretion of diazepam metabolites in healthy volunteers and drug users

被引：0
|
作者：
Smith-Kielland, A [1 ]
Skuterud, B [1 ]
Olsen, KM [1 ]
Morland, J [1 ]
机构：
[1] Natl Inst Forens Toxicol, N-0105 Oslo, Norway
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2001年 / 61卷 / 03期
关键词：
benzodiazepines; creatinine; drug testing; N-desmethyldiazepam; oxazepam; 3-OH-diazepam;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Urinary excretion profiles of diazepam metabolites were investigated. The subjects were healthy volunteers receiving one single 10-mg dose of diazepam or drug abusers starting a prison sentence. Urinary excretion of metabolites was analysed by immunological screening, liquid chromatography and gas chromatography-mass spectrometry. Relating the metabolite concentration to creatinine concentration in the specimens decreased sample-to-sample variations. In some cases such correction could protect a subject from erroneous accusations of a new intake.
引用
收藏
页码：237 / 246
页数：10
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