Synthesis and antiviral bioactivities of 2-aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-quinazolinone derivatives

被引：57

作者：

Gao, Xingwen ^{[1
]}

Cai, Xuejian ^{[1
]}

Yan, Kai ^{[1
]}

Song, Baoan ^{[1
]}

Gao, Lili ^{[1
]}

Chen, Zhuo ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

MOLECULES | 2007年 / 12卷 / 12期

关键词：

4(3H)-quinazolinone; schiff base; synthesis; antiviral activity;

D O I：

10.3390/12122621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and general method has been developed for the synthesis of various 4(3H)-quinazolinone derivatives by the treatment of the appropriate 3-amino-2-aryl-4(3H)-quinazolinone with a substituted benzaldehyde in ethanol. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and C-13-NMR spectra. The title 2aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-quinazolinone compounds III-1 similar to III-31 were found to possess moderate to good antiviral activity. Semi-quantitative PCR and Real Time PCR assays were used to ascertain the target of action of compound III-31 against TMV. The studies suggest that III-31 possesses antiviral activity due to induction of up-regulation of PR-1a and PR-5, thereby inhibiting virus proliferation and movement by enhancement of the activity of some defensive enzyme.

引用

页码：2621 / 2642

页数：22

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