Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives

被引:14
|
作者
Hobley, Gerard [1 ]
Gubala, Vladimir [1 ]
Rivera-Sanchez, Maria Del C. [1 ]
Rivera, Jose M. [1 ]
机构
[1] Univ Puerto Rico, Coll Nat Sci, Dept Chem, San Juan, PR 00931 USA
关键词
Stille reaction; nucleosides; nucleobases; palladium; coupling;
D O I
10.1055/s-2007-1077795
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.
引用
收藏
页码:1510 / 1514
页数:5
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