Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives

被引：14

作者：

Hobley, Gerard ^{[1
]}

Gubala, Vladimir ^{[1
]}

Rivera-Sanchez, Maria Del C. ^{[1
]}

Rivera, Jose M. ^{[1
]}

机构：

[1] Univ Puerto Rico, Coll Nat Sci, Dept Chem, San Juan, PR 00931 USA

来源：

SYNLETT | 2008年 / 10期

关键词：

Stille reaction; nucleosides; nucleobases; palladium; coupling;

D O I：

10.1055/s-2007-1077795

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

引用

页码：1510 / 1514

页数：5

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