The Role of Type I and Type II NKT Cells in Materno-Fetal Immunity

被引：11

作者：

Miko, Eva ^{[1
,2
,3
]}

Barakonyi, Aliz ^{[1
,2
,3
]}

Meggyes, Matyas ^{[1
,2
]}

Szereday, Laszlo ^{[1
,2
]}

机构：

[1] Univ Pecs, Med Sch, Dept Med Microbiol & Immunol, 12 Szigeti St, H-7624 Pecs, Hungary

[2] Janos Szentagothai Res Ctr, 20 Ifjusag St, H-7624 Pecs, Hungary

[3] Univ Pecs, Natl Lab Human Reprod, H-7624 Pecs, Hungary

来源：

BIOMEDICINES | 2021年 / 9卷 / 12期

关键词：

type I NKT; type II NKT; reproductive immunology; materno-fetal interface; implantation failure; pregnancy loss; mouse; human; NATURAL-KILLER-T; RECURRENT REPRODUCTIVE FAILURE; PERIPHERAL-BLOOD; REGULATORY T; ALPHA-GALACTOSYLCERAMIDE; PREGNANCY LOSS; LEVELS PREDICT; PRETERM BIRTH; CUTTING EDGE; EXPRESSION;

D O I：

10.3390/biomedicines9121901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NKT cells represent a small but significant immune cell population as being a part of and bridging innate and adaptive immunity. Their ability to exert strong immune responses via cytotoxicity and cytokine secretion makes them significant immune effectors. Since pregnancy requires unconventional maternal immunity with a tolerogenic phenotype, investigation of the possible role of NKT cells in materno-fetal immune tolerance mechanisms is of particular importance. This review aims to summarize and organize the findings of previous studies in this field. Data and information about NKT cells from mice and humans will be presented, focusing on NKT cells characteristics during normal pregnancy in the periphery and at the materno-fetal interface and their possible involvement in female reproductive failure and pregnancy complications with an immunological background.

引用

页数：12

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