Exact distribution of the local score for markovian sequences

被引:7
|
作者
Hassenforder, Claudie [1 ]
Mercier, Sabine [1 ]
机构
[1] Univ Toulouse 2, Equipe GRIMM, Dept Math & Informat, UFR SES, F-31058 Toulouse 9, France
关键词
markov chain; local score; p-value; sequence analysis;
D O I
10.1007/s10463-006-0064-6
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Let A = (A(i))(1 <= i <= n) be a sequence of letters taken in a finite alphabet Theta. Let s : Theta --> Z be a scoring function and X = (X-i)(1 <= i <= n) the corresponding score sequence where X-i = s(A(i)). The local score is defined as follows: H-n = max(1 <= i <= j <= n) Sigma(j)(k= i) X-k. We provide the exact distribution of the local score in random sequences in several models. We will first consider a Markov model on the score sequence X, and then on the letter sequence A. The exact P-value of the local score obtained with both models are compared thanks to several datasets. They are also compared with previous results using the independent model.
引用
收藏
页码:741 / 755
页数:15
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