Isobolographic Analysis of the Interaction Between Tapentadol and Ketorolac in a Mouse Model of Visceral Pain

被引：8
|
作者：
Zapata-Morales, Juan R. [1 ]
Aragon-Martinez, Othoniel H. [2 ]
Adriana Soto-Castro, Tely [3 ]
Alonso-Castro, Angel J. [1 ]
Castaneda-Santana, Demian I. [4 ]
Isiordia-Espinoza, Mario A. [3 ]
机构：
[1] Univ Guanajuato, Div Ciencias Nat & Exactas, Dept Farm, Guanajuato, Mexico
[2] Univ Autonoma San Luis Potosi, Fac Med, Dept Farmacol, Slp, Mexico
[3] Univ Autonoma Baja California, Fac Odontol, Dept Farmacol, Campus Mexicali, Mexicali, Baja California, Mexico
[4] Ctr Educ Avanzada, Dept Invest, Tepic, Nayarit, Mexico
来源：
DRUG DEVELOPMENT RESEARCH | 2016年 / 77卷 / 04期
关键词：
tapentadol; ketorolac; acute visceral pain test; isobolographic analysis; OROFACIAL FORMALIN TEST; ANTINOCICEPTIVE ACTIVITY; ANTIINFLAMMATORY DRUGS; NOR-BINALTORPHIMINE; SPINAL SYNERGISM; MORPHINE; TRAMADOL; DICLOFENAC; NSAIDS; RATS;
D O I：
10.1002/ddr.21310
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of this experimental assay was to assess the antinociceptive interaction between tapentadol and ketorolac in the acetic acid-induced writhing model in mice. Tapentadol (5.62-31.6 mg/kg ip) or ketorolac (5.62-31.6 mg/kg ip) were administered 15 min before the acetic acid administration. The ED50 values of the individual drugs were determined and different proportions (tapentadol-ketorolac in 1:1, 3:1, and 1:3) were assayed in combination in the writhing test. Isobolographic analysis and the interaction index demonstrated an antinociceptive synergistic interaction between tapentadol and ketorolac in all combination. Thus, the experimental ED50 values were lower when compared with their theoretical ED50 values. These data suggest that the tapentadol-ketorolac combination produces an antinociceptive synergistic interaction in the mouse acetic acid-induced writhing model. Drug Dev Res 77 : 187-191, 2016. (c) 2016 Wiley Periodicals, Inc.
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页码：187 / 191
页数：5
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