A novel and chiral synthesis of both enantiomers of trans-3-amino-4-hydroxyhexahydroazepine, a key intermediate for the synthesis of balanol

被引：0
|
作者：
Naito, T
Torieda, M
Tajiri, K
Ninomiya, I
Kiguchi, T
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 03期
关键词：
balanol; 3-amino-4-hydroxyhexahydroazepine; oxime ether; radical cyclization; chiral synthesis; PKC inhibitor;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Both enantiomers of the hexahydroazepine (7), key intermediates for the synthesis of (-)-balanol (1) and its enantiomer, were effectively synthesized via the shortest route involving stannyl radical cyclization of the aldehyde (4) connected with oxime ether followed by the optical resolution of the resulting azepine (7).
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页码：624 / 626
页数：3
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