Regioselective synthesis of functionalized [1,8]-naphthyridine derivatives via three-component domino reaction under catalyst-free conditions

被引：19

作者：

Feng, Xian ^{[1
]}

Wang, Jian-Jun ^{[1
]}

Zhang, Juan-Juan ^{[1
]}

Cao, Cheng-Pao ^{[1
]}

Huang, Zhi-Bin ^{[1
]}

Shi, Da-Qing ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

GREEN CHEMISTRY | 2015年 / 17卷 / 02期

关键词：

ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; SOLVENT-FREE; SPIROOXINDOLE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; ANTIINFLAMMATORY ACTIVITY; N; S-KETENE ACETAL; 4-COMPONENT; ANTICANCER;

D O I：

10.1039/c4gc01469c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise and efficient one-pot synthesis of functionalized [1,8] naphthyridine derivatives via a three-component domino reaction of glutaraldehyde, malononitrile, and beta-ketoamides, under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. The main advantages of this protocol are short reaction times, practical simplicity, high yields, catalyst-free conditions, cheap and benign solvents, and high regio- and stereo-selectivities.

引用

页码：973 / 981

页数：9

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