Tenofovir Exposure during Pregnancy and Postpartum in Women Receiving Tenofovir Disoproxil Fumarate for the Prevention of Mother-to-Child Transmission of Hepatitis B Virus

被引：3

作者：

Cressey, Tim R. ^{[1
,2
,3
]}

Harrison, Linda ^{[4
]}

Achalapong, Jullapong ^{[5
]}

Kanjanavikai, Prateep ^{[6
]}

Ayudhaya, Orada Patamasingh Na ^{[7
]}

Liampongsabuddhi, Prateung ^{[8
]}

Siriwachirachai, Thitiporn ^{[9
]}

Putiyanun, Chaiwat ^{[10
]}

Suriyachai, Pornnapa

Tierney, Camlin ^{[4
]}

Salvadori, Nicolas ^{[1
]}

Chinwong, Dujrudee ^{[11
]}

Decker, Luc ^{[12
]}

Tawon, Yardpiroon ^{[1
]}

Murphy, Trudy V. ^{[13
]}

Ngo-Giang-Huong, Nicole ^{[1
,2
,12
]}

Siberry, George K. ^{[14
]}

Jourdain, Gonzague ^{[1
,2
,11
]}

机构：

[1] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, PHPT IRD, Chiang Mai, Thailand

[2] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[4] Harvard TH Chan Sch Publ Hlth, CBAR, Boston, MA USA

[5] Chiangrai Prachanukroh Hosp, Chiang Rai, Thailand

[6] Banglamung Hosp, Chon Buri, Thailand

[7] Nopparat Rajathanee Hosp, Bangkok, Thailand

[8] Lampang Hosp, Lampang, Thailand

[9] Khon Kaen Hosp, Khon Kaen, Thailand

[10] Chiang Kham Hosp, Phayao, Thailand

[11] Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Care, Chiang Mai, Thailand

[12] IRD, Unite Mixte Int PHPT 174, Chiang Mai, Thailand

[13] Ctr Dis Control & Prevent, Atlanta, GA USA

[14] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 12期

关键词：

pregnancy; tenofovir; hepatitis B virus; pharmacokinetics; CLINICAL-PHARMACOLOGY; PHARMACOKINETICS; HIV;

D O I：

10.1128/AAC.01686-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed tenofovir exposure during pregnancy and postpartum in hepatitis B virus (HBV)-infected HIV-uninfected women receiving tenofovir disoproxil fumarate (TDF) to prevent mother-to-child transmission of HBV. Data from 154 women who received TDF within a randomized controlled trial were included. Individual plasma tenofovir exposures (area under the concentration-time curve from 0 to 24 h [AUC0-24]) were estimated using a population pharmacokinetic approach. The estimated geometric mean tenofovir AUC(0-24) was 20% (95% confidence interval [95% CI], 19 to 21%) lower during pregnancy than during postpartum; this modest reduction in the absence of HBV transmission suggests that no dose adjustment is needed.

引用

页数：5

共 50 条

[41] Letter: put on your thinking cap - tenofovir disoproxil fumarate for the prevention of vertical transmission of hepatitis B virus
Vyas, Ashish K.
Jindal, Ankur
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 49 (06) : 823 - 824
[42] The role of tenofovir disoproxil fumarate for preventing vertical transmission of hepatitis B
Pan, Calvin Q.
[J]. ANTIVIRAL THERAPY, 2022, 27 (02)
[43] Prevention of the mother-to-child transmission of Hepatitis B virus
Pol, Stanislas
Jourdain, Gonzague
[J]. LIVER INTERNATIONAL, 2018, 38 (07) : 1177 - 1178
[44] Editorial: tenofovir alafenamide fumarate-a new bullet to prevent mother-to-child transmission of hepatitis B virus. Authors' reply
Pan, Calvin Q.
Cao, Lihua
Huang, Yan
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 52 (11-12) : 1746 - 1747
[45] Letter: role of tenofovir to prevent mother-to-child transmission of hepatitis B virus-authors' reply
Lee, Y. -S.
Hyun, M. H.
Kim, J. H.
Yeon, J. E.
Byun, K. S.
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2017, 46 (05) : 563 - 564
[46] Tenofovir to prevent mother-to-child transmission of hepatitis B virus: systematic review with meta-analysis
Kanninen, Tomi T.
Sisti, Giovanni
Moretti, Michael
Lakhi, Nisha
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2019, 220 (01) : S434 - S435
[47] Tenofovir disoproxil fumarate safety for women and their infants during pregnancy and breastfeeding
Mofenson, Lynne M.
Baggaley, Rachel C.
Mameletzis, Loannis
[J]. AIDS, 2017, 31 (02) : 213 - 232
[48] Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate
Kaneko, Shun
Kurosaki, Masayuki
Tamaki, Nobuharu
Itakura, Jun
Hayashi, Tsuguru
Kirino, Sakura
Osawa, Leona
Watakabe, Keiya
Okada, Mao
Wang, Wan
Shimizu, Takao
Higuchi, Mayu
Takaura, Kenta
Yasui, Yutaka
Tsuchiya, Kaoru
Nakanishi, Hiroyuki
Takahashi, Yuka
Watanabe, Mamoru
Izumi, Namiki
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 34 (11) : 2004 - 2010
[49] Efficacy of Third Trimester Maternal Tenofovir Disoproxil Fumarate Treatment in Interrupting Mother-to-Infant Transmission of Hepatitis B Virus
Chen, Huey-Ling
Lee, Chien-Nan
Chang, Chin-Hao
Ni, Yen-Hsuan
Chen, Shih-Ming
Hu, Jen-Jan
Lin, Hans Hsienhong
Mu, Shu-Chi
Lai, Ming-Wei
Tsai, Ming-Song
Chen, Ding-Shinn
Chan, K. Arnold
Chang, Mei-Hwei
[J]. HEPATOLOGY, 2014, 60 : 984A - 984A
[50] Maternal and Infant Bone Mineral Density 1 Year After Delivery in a Randomized, Controlled Trial of Maternal Tenofovir Disoproxil Fumarate to Prevent Mother-to-child Transmission of Hepatitis B Virus
Salvadori, Nicolas
Fan, Bo
Teeyasoontranon, Waralee
Ngo-Giang-Huong, Nicole
Phanomcheong, Siriluk
Luvira, Anita
Puangsombat, Achara
Suwannarat, Arunrat
Srirompotong, Ussanee
Putiyanun, Chaiwat
Cressey, Tim R.
Decker, Luc
Khamduang, Woottichai
Harrison, Linda
Tierney, Camlin
Shepherd, John A.
Kourtis, Athena P.
Bulterys, Marc
Siberry, George K.
Jourdain, Gonzague
[J]. CLINICAL INFECTIOUS DISEASES, 2019, 69 (01) : 144 - 146

← 1 2 3 4 5 →