Tenofovir Exposure during Pregnancy and Postpartum in Women Receiving Tenofovir Disoproxil Fumarate for the Prevention of Mother-to-Child Transmission of Hepatitis B Virus

被引：3

作者：

Cressey, Tim R. ^{[1
,2
,3
]}

Harrison, Linda ^{[4
]}

Achalapong, Jullapong ^{[5
]}

Kanjanavikai, Prateep ^{[6
]}

Ayudhaya, Orada Patamasingh Na ^{[7
]}

Liampongsabuddhi, Prateung ^{[8
]}

Siriwachirachai, Thitiporn ^{[9
]}

Putiyanun, Chaiwat ^{[10
]}

Suriyachai, Pornnapa

Tierney, Camlin ^{[4
]}

Salvadori, Nicolas ^{[1
]}

Chinwong, Dujrudee ^{[11
]}

Decker, Luc ^{[12
]}

Tawon, Yardpiroon ^{[1
]}

Murphy, Trudy V. ^{[13
]}

Ngo-Giang-Huong, Nicole ^{[1
,2
,12
]}

Siberry, George K. ^{[14
]}

Jourdain, Gonzague ^{[1
,2
,11
]}

机构：

[1] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, PHPT IRD, Chiang Mai, Thailand

[2] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[4] Harvard TH Chan Sch Publ Hlth, CBAR, Boston, MA USA

[5] Chiangrai Prachanukroh Hosp, Chiang Rai, Thailand

[6] Banglamung Hosp, Chon Buri, Thailand

[7] Nopparat Rajathanee Hosp, Bangkok, Thailand

[8] Lampang Hosp, Lampang, Thailand

[9] Khon Kaen Hosp, Khon Kaen, Thailand

[10] Chiang Kham Hosp, Phayao, Thailand

[11] Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Care, Chiang Mai, Thailand

[12] IRD, Unite Mixte Int PHPT 174, Chiang Mai, Thailand

[13] Ctr Dis Control & Prevent, Atlanta, GA USA

[14] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 12期

关键词：

pregnancy; tenofovir; hepatitis B virus; pharmacokinetics; CLINICAL-PHARMACOLOGY; PHARMACOKINETICS; HIV;

D O I：

10.1128/AAC.01686-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed tenofovir exposure during pregnancy and postpartum in hepatitis B virus (HBV)-infected HIV-uninfected women receiving tenofovir disoproxil fumarate (TDF) to prevent mother-to-child transmission of HBV. Data from 154 women who received TDF within a randomized controlled trial were included. Individual plasma tenofovir exposures (area under the concentration-time curve from 0 to 24 h [AUC0-24]) were estimated using a population pharmacokinetic approach. The estimated geometric mean tenofovir AUC(0-24) was 20% (95% confidence interval [95% CI], 19 to 21%) lower during pregnancy than during postpartum; this modest reduction in the absence of HBV transmission suggests that no dose adjustment is needed.

引用

页数：5

共 50 条

[1] Editorial: tenofovir disoproxil fumarate and prevention of mother-to-child transmission of hepatitis B virus
Han, Zhenyan
Hou, Hongying
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 50 (06) : 707 - 708
[2] Letter: tenofovir disoproxil fumarate is safe for prevention of mother-to-child transmission of hepatitis B virus
Fan, Li-Wei
Zhao, Chang
Ma, Yi-Long
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 50 (04) : 475 - 476
[3] Proximal tubular dysfunction in pregnant women receiving tenofovir disoproxil fumarate to prevent mother-to-child transmission of hepatitis B virus
Liegeon, Geoffroy
Ngo-Giang-Huong, Nicole
Salvadori, Nicolas
Bunpo, Piyawan
Cressey, Ratchada
Achalapong, Jullapong
Kanjanavikai, Prateep
Ayudhaya, Orada Patamasingh Na
Prommas, Sinart
Siriwachirachai, Thitiporn
Sabsanong, Prapan
Mary, Jean Yves
Jourdain, Gonzague
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2022, 77 (04) : 1111 - 1118
[4] Editorial: tenofovir disoproxil fumarate and prevention of mother-to-child transmission of hepatitis B virus-authors' reply
Chang, Kai-Chi
Chang, Mei-Hwei
Lin, Lung-Huang
Chen, Huey-Ling
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 50 (06) : 708 - 709
[5] THE EFFICACY AND SAFETY OF TELBIVUDINE OR TENOFOVIR DISOPROXIL IN PREGNANCY FOR PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B VIRUS
Huang, H.
Zhang, Y.
Wu, Q.
Wang, Y.
[J]. JOURNAL OF HEPATOLOGY, 2015, 62 : S560 - S560
[6] The Efficacy And Safety Of Telbivudine And/Or Tenofovir Disoproxil In Pregnancy For Prevention Of Mother-To-Child Transmission Of Hepatitis B Virus
Zhang, Yanqiong
Huang, Hongfei
Wu, Quanxin
Wang, Yuming
[J]. HEPATOLOGY, 2015, 62 : 1195A - 1195A
[7] Tenofovir Disoproxil: Effective and Safe in Prevention of Mother-to-child Transmission of Hepatitis B Virus
Huang, Hongfei
Wu, Quanxin
Wang, Yuming
[J]. HEPATOLOGY, 2014, 60 : 1088A - 1088A
[8] Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review
Baciu, Iulia
Domuncu, Dalila-Ana
Domuncu, Tiberiu
Ciobanu, Anca Marina
Voiosu, Theodor
Peltecu, Gheorghe
Panaitescu, Anca Maria
[J]. CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2021, 48 (01): : 9 - 18
[9] Letter: tenofovir disoproxil fumarate is safe for prevention of mother-to-child transmission of hepatitis B virus. Authors' reply
Pan, Calvin Q.
Zhang, Hua
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 50 (04) : 477 - 478
[10] Critical Insights Into the Effectiveness and Safety of Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in Preventing Mother-to-Child Transmission of Hepatitis B Virus
Hao, Lu
Xue, Jisu
[J]. CLINICAL INFECTIOUS DISEASES, 2024,

← 1 2 3 4 5 →